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Professor of Cellular Biology

   Johannes M. Herrmann

 


    Curriculum vitae:

  • 1986 - 1992 Biology at the Universities of Bayreuth and Tübingen
  • 1990 - 1991 Diploma student at the Federal Research Centre for Viral Diseases of Animals in Tübingen
  • 1992 - 1996 PhD student in the laboratory of Walter Neupert at the Department of Physiological Chemistry in Munich
  • 1996 - 1998 Postdoc in the laboratory of Randy Schekman at the University of California in Berkeley, USA
  • 1999 - 2006 Group leader (wissenschaftlicher Assistent) in the Department of Physiological Chemistry at the Adolf-Butenandt Institute in Munich
  • 2006 - Arnold Sommerfeld Award of the Bavarian Academy of Sciences
  • since 2006 - Professor of Cell Biology, Faculty of Biology, University of Kaiserslautern. Head of the Department
  • 2008 - Personal Teaching Award, Rheinland-Pfalz
  • 2008 - 2009 Vice Dean of the Biological Faculty
  • Feb 2009 -  Feb 2012 Dean of the Biological Faculty
  • 2010 - Award for Excellent Teaching in Rheinland-Pfalz
  • 2011 - FEBS National Lecture Award, Brussels
  • 2012 - Membership on Editorial Boards of Biological Chemistry and of Biomolecules

Major Research Interest:

One main focus of our group is the biogenesis of proteins of the mitochondrial inner membrane which belongs to the protein-richest membranes of the eukaryotic cell. The inner membrane accommodates a large number of different integral membrane proteins which, typically assembled in multiprotein complexes, perform a variety of functions like the transport of molecules or generation of ATP. We analyze how these proteins are inserted into the inner membrane, and especially focus on the membrane integration and assembly of mitochondrial translation products.

The second aspect of our research addresses the biogenesis of proteins of the intermembrane space of mitochondria. This compartment contains factors which are essential for energy metabolism, metabolite and protein transport or apoptosis. Several of these proteins contain cysteine residues which are oxidized in the intermembrane space forming intramolecular disulfide bridges. We characterize the machinery which catalyses protein oxidation and analyse its relevance in vitro and in vivo.

Selected Recent Publications:

Longen S, Woellhaf MW, Petrungaro C, Riemer J, Herrmann JM. 2013. The Disulfide Relay of the Intermembrane Space Oxidizes the Ribosomal Subunit Mrp10 on Its Transit into the Mitochondrial Matrix. Developmental Cell 28, 30-42

Fischer M, Horn S, Belkacemi A, Kojer K, Petrungaro C, Habich M, Ali M, Kuttner V, Bien M, Kauff F, Dengjel J, Herrmann JM, Riemer J. 2013. Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells   Mol. Biol. Cell 24, 2160-70

Weckbecker D, Longen S, Riemer J, Herrmann JM. 2012. Atp23 biogenesis reveals a chaperone-like folding activity of Mia40 in the IMS of mitochondria. EMBO J. 31, 4348-4358

Bien M, Longen S, Wagener N, Chwalla I, Herrmann JM, Riemer J. 2010. Mitochondrial Disulfide Bond Formation Is Driven by Intersubunit Electron Transfer in Erv1 and Proofread by Glutathione. Mol Cell 37, 516-28

Riemer J, Bulleid N, Herrmann JM. 2009. Disulfide formation in the ER and mitochondria: two solutions to a common process. Science 324, 1284-7

Funes S, Hasona A, Bauerschmitt H, Grubbauer C, Kauff F, Collins R, Crowley PJ, Palmer SR, Brady LJ, Herrmann JM. 2009. Independent gene duplications of the YidC/Oxa/Alb3 family enabled a specialized cotranslational function. PNAS 106, 6656-61

Bihlmaier K, Mesecke N, Terziyska N, Bien M, Hell K, Herrmann JM 2007. The disulfide relay system of mitochondria is connected to the respiratory chain. J Cell Biol 179, 389-395

Neupert W, Herrmann JM 2007. Translocation of Proteins into Mitochondria. Annu Rev Biochem 76, 723-49

Mesecke N, Terziyska N, Kozany C, Baumann F, Neupert W, Hell K, Herrmann JM. 2005. A disulfide relay system in the intermembrane space of mitochondria that mediates protein import. Cell 121, 1059-1069