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Peer-Reviewed Publications

Thermodynamics of nanodisc formation mediated by styrene/maleic acid (2:1) copolymer.
Grethen A, Oluwole AO, Danielczak B, Vargas C, Keller S.
Sci. Rep. 20177, 11517.
PubMed  

Structural and molecular comparison of bacterial and eukaryotic trigger factors.
Ries F, Carius Y, Rohr M, Gries K, Keller S, Lancaster CRD, Willmund F.
Sci. Rep. 20177, 10680.
PubMed

Slow interconversion in a conformationally heterogeneous unfolded-state ensemble of Outer Membrane Phospholipase A.
Krainer G, Gracia P, Frotscher E, Hartmann A, Gröger P, Keller S, Schlierf M.
Biophys. J. 201717, 30576-30583.
PubMed

Fast collisional lipid transfer among polymer-bounded nanodiscs.
Cuevas Arenas R, Danielczak B, Martel A, Porcar L, Breyton C, Ebel C, Keller S.
Sci. Rep. 20177, 45875.
PubMed

Real-time visualization of phospholipid degradation by outer membrane phospholipase A using high-speed atomic force microscopy.
Rangl M, Rima L, Klement J, Miyagi A, Keller S, Scheuring S.
J. Mol. Biol. 2017429, 977–986.
PubMed

Model-free analysis of critical micellar concentrations for detecting demixing in surfactant mixtures.
Frotscher E, Höring J, Durand G, Vargas C, Keller S.
Anal. Chem. 201789, 3245–3249.
PubMed

Solubilization of membrane proteins into functional lipid-bilayer nanodiscs by diisobutylene/maleic acid copolymer. 
Oluwole AO, Danielczak B, Meister A, Babalola JO, Vargas C, Keller S.  
Angew. Chem. Int. Ed. 201756, 1919–1924.
PubMed

Oxoanion binding to a cyclic pseudopeptide containing 1,4-disubstituted 1,2,3-triazole moieties.
Mungalpara D, Kelm H, Valkonen A, Keller S, Kubik S.
Org. Biomol. Chem. 201615, 102–113.
PubMed

Influence of lipid bilayer properties on nanodisc formation mediated by styrene/maleic acid copolymers.
Cuevas Arenas R, Klingler J, Vargas C, Keller S.
Nanoscale 20168, 15016–15026.
PubMed

Journal of Membrane Biology: Biophysics.
Keller S, Bondar AN, Broecker J, Ladokhin AS, Sinner EK.
J Membr Biol. 2016, 249, 5–5.

Sparingly fluorinated maltoside-based surfactants for membrane-protein stabilization.
Polidori A, Raynal S, Barret LA, Dahani M, Barrot-Ivolot C, Jungas C, Frotscher E, Keller S, Ebel C, Breyton C, Bonneté F. 
New J. Chem. 2016, 40, 5364–5378.

Integration and global analysis of isothermal titration calorimetry data for studying macromolecular interactions.
Brautigam CA, Zhao H, Vargas C, Keller S, Schuck P.
Nat. Protoc. 201611, 882–894.
PubMed

Reversible unfolding of rhomboid intramembrane proteases.
Panigrahi R, Arutyunova E, Panwar P, Gimpl K, Keller S, Lemieux MJ.
Biophys. J. 2016110, 1379–1390.
PubMed

Characterising protein/detergent complexes by triple-detection size-exclusion chromatography.
Gimpl K, Klement J, Keller S.
Biol. Proced. Online 201618, 4.
PubMed

Calorimetric quantification of cyclodextrin-mediated detergent extraction for membrane-protein reconstitution.
Textor M, Keller S.
Methods Enzymol. 2016567, 129–156.
PubMed

Nanoparticle self-assembly in mixtures of phospholipids with styrene/maleic acid copolymers or fluorinated surfactants.
Vargas C, Cuevas Arenas R, Frotscher E, Keller S.
Nanoscale 20157, 20685–20696.
PubMed

Quantification of millisecond protein-folding dynamics in membrane-mimetic environments by single-molecule FRET spectroscopy.
Hartmann A, Krainer G, Keller S, Schlierf M.
Anal. Chem. 201587, 11224–11232.
PubMed

Multiple multidentate halogen bonding in solution, in the solid state, and in the (calculated) gas phase.
Jungbauer SH, Schindler S, Herdtweck E, Keller S, Huber SM.
Chemistry 201521, 13625–13636.
PubMed

Structural thermodynamics of myr-Src(2–19) binding to phospholipid membranes.
Scheidt HA, Klingler J, Huster D, Keller S.
Biophys. J. 2015109, 586–594.
PubMed

Automated analysis of calorimetric demicellisation titrations.
Textor M, Keller S.
Anal. Biochem. 2015, 485, 119–121.
PubMed

Modulating bilayer mechanical properties to promote the coupled folding and insertion of an integral membrane protein.
Herrmann M, Danielczak B, Textor M, Klement J, Keller S.
Eur. Biophys. J. 201544, 503–512.
PubMed

Biocalorimetry.
Chaires JB, Hansen LD, Keller S, Brautigam CA, Zhao H, Schuck P.
Methods 2015, 76, 1–2.
PubMed

A fluorinated detergent for membrane-protein applications.
Frotscher E, Danielczak B, Vargas C, Meister A, Durand G, Keller S.
Angew. Chem. Int. Ed. 2015, 54, 5069–5073.
PubMed

Preparation of ready-to-use small unilamellar phospholipid vesicles by ultrasonication with a beaker resonator.
Klingler J, Vargas C, Fiedler S, Keller S.
Anal. Biochem. 2015, 477, 10–12.
PubMed

Micellar and biochemical properties of a propyl-ended fluorinated surfactant designed for membrane-protein study.
Abla M, Unger S, Keller S, Bonneté F, Ebel C, Pucci B, Breyton C, Durand G.
J. Colloid Interface Sci. 2015, 445, 127–136.
PubMed

Calorimetric quantification of linked equilibria in cyclodextrin/lipid/detergent mixtures for membrane-protein reconstitution.
Textor M, Vargas C, Keller S.
Methods 2015, 76, 183–193.
PubMed

Single-experiment displacement assay for quantifying high-affinity binding by isothermal titration calorimetry.
Krainer G, Keller S.
Methods 2015, 76, 116–123.
PubMed

Sequence-specific dimerization of a transmembrane helix in amphipol A8-35.
Stangl M, Unger S, Keller S, Schneider D.
PLoS One 2014, 9, e110970.
PubMed

Mistic's membrane association and its assistance in overexpression of a human GPCR are independent processes.
Marino J, Bordag N, Keller S, Zerbe O.
Protein Sci. 201524, 38–48.
PubMed

Self-assembly thermodynamics of pH-responsive amino acid-based polymers with a non-ionic surfactant.
Bogomolova AY, Keller S, Klingler J, Sedlak M, Rak D, Sturcova A, Hruby M, Stepanek P, Filippov SK.
Langmuir 2014, 30, 11307–11318.
PubMed

Polar interactions trump hydrophobicity in stabilizing the self-inserting membrane protein Mistic.
Broecker J, Fiedler S, Gimpl K, Keller S.
J. Am. Chem. Soc. 2014, 136, 13761–13768.
PubMed

Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain.
Baumkötter F, Schmidt N, Vargas C, Schilling S, Weber R, Wagner K, Fiedler S, Klug W, Radzimanowski J, Nickolaus S, Keller S, Eggert S, Wild K, Kins S.
J. Neurosci. 2014, 34, 11159–11172.
PubMed

Analysis of selected and designed chimeric D- and L-α-helix assemblies.
Kükenshöner T, Hagemann UB, Wohlwend D, Räuber C, Baumann T, Keller S, Einsle O, Müller KM, Arndt KM.
Biomacromolecules 2014, 15, 3296–3305.
PubMed

Small-molecule inhibitors of AF6 PDZ-mediated protein–protein interactions.
Vargas C, Radziwill G, Krause G, Diehl A, Keller S, Kamdem N, Czekelius C, Kreuchwig A, Schmieder P, Doyle D, Moelling K, Hagen V, Schade M, Oschkinat H.
ChemMedChem 2014, 9, 1458–1462.
PubMed

Structure–activity relationships of the antimicrobial peptide gramicidin S and its analogues: aqueous solubility, self association, conformation, antimicrobial activity and interactions with model lipid membranes.
Abraham T, Prenner EJ, Lewis RN, Mant CT, Keller S, Hodges RS, McElhaney RN.
Biochim. Biophys. Acta 2014, 1838, 1420–1429.
PubMed

New and Notable: How membrane partitioning modulates receptor activation: parallel versus serial effects of hydrophobic ligands.
Heerklotz H, Keller S.
Biophys. J. 2013105, 2607–2610.
PubMed

Real-time monitoring of membrane-protein reconstitution by isothermal titration calorimetry.
Jahnke N, Krylova O, Hoomann T, Vargas C, Fiedler S, Pohl P, Keller S.
Anal. Chem. 2014, 86, 920–927.
PubMed

The mechanism of denaturation and the unfolded state of the α-helical membrane-associated protein Mistic.
Jacso T, Bardiaux B, Broecker J, Fiedler S, Baerwinkel T, Mainz A, Fink U, Vargas C, Oschkinat H, Keller S, Reif B.
J. Am. Chem. Soc. 2013, 135, 18884–18891.
PubMed

Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels.
Vocke K, Dauner K, Hahn A, Ulbrich A, Broecker J, Keller S, Frings S, Möhrlen F.
J. Gen. Physiol. 2013, 142, 381–404.
PubMed

Membrane partitioning and translocation studied by isothermal titration calorimetry.
Vargas C, Klingler J, Keller S.
Methods Mol. Biol. 2013, 1033, 253–271.
PubMed

Filter gate closure inhibits ion but not water transport through potassium channels.
Hoomann T, Jahnke N, Horner A, Keller S, Pohl P.
Proc. Natl. Acad. Sci. USA 2013, 110, 10842–10847.
PubMed

Impact of urea on detergent micelle properties.
Broecker J, Keller S.
Langmuir 2013, 29, 8502–8510.
PubMed

Automated circular dichroism spectroscopy for medium-throughput analysis of protein conformation.
Fiedler S, Cole L, Keller S.
Anal. Chem. 2013, 85, 1868–1872.
PubMed

Quantifying high-affinity binding of hydrophobic ligands by isothermal titration calorimetry.
Krainer G, Broecker J, Vargas C, Fanghänel J, Keller S.
Anal. Chem. 2012, 84, 10715–10722.
PubMed

Coumarin-based octopamine phototriggers and their effects on an insect octopamine receptor.
Schaal J, Dekowski B, Wiesner B, Eichhorst J, Marter K, Vargas C, Keller S, Eremina N, Barth A, Baumann A, Eisenhardt D, Hagen V.
ChemBioChem 2012, 13, 1458–1464.
PubMed

High-precision isothermal titration calorimetry with automated peak-shape analysis.
Keller S, Vargas C, Zhao H, Piszczek G, Brautigam CA, Schuck P.
Anal. Chem. 2012, 84, 5066–5073.
PubMed

Ring A of nukacin ISK-1: a lipid II-binding motif for type-A(II) lantibiotic.
Islam MR, Nishie M, Nagao J, Keller S, Nakayama J, Kohda D, Sahl HG, Sonomoto K.
J. Am. Chem. Soc. 2012, 134, 3687–3690.
PubMed

Mutations of ventricular essential myosin light chain disturb myosin binding and sarcomeric sorting.
Lossie J, Ushakov DS, Ferenczi MA, Werner S, Keller S, Haase H, Morano I.
Cardiovasc. Res. 2012, 93, 390–396.
PubMed

Characterization of membrane proteins in isolated native cellular membranes by dynamic nuclear polarization solid-state NMR spectroscopy without purification and reconstitution.
Jacso T, Franks WT, Rose H, Fink U, Broecker J, Keller S, Oschkinat H, Reif B.
Angew. Chem. Int. Ed. 2012, 51, 432–435.
PubMed

Mia40-dependent oxidation of cysteines in domain I of Ccs1 controls its distribution between mitochondria and the cytosol.
Klöppel C, Suzuki Y, Kojer K, Petrungaro C, Longen S, Fiedler S, Keller S, Riemer J.
Mol. Biol. Cell 201122, 3749–3757.
PubMed

Revisiting the optimal c value for isothermal titration calorimetry.
Broecker J, Vargas C, Keller S.
Anal. Biochem. 2011, 418, 307–309.
PubMed

Distinct binding properties distinguish LQ-type calmodulin-binding domains in cyclic nucleotide-gated channels. 
Ungerer N, Mücke N, Broecker J, Keller S, Frings S, Möhrlen F. 
Biochemistry 2011, 50, 3221–3228.
PubMed

Human essential myosin light chain isoforms revealed distinct myosin binding, sarcomeric sorting, and inotropic activity.
Petzhold D, Lossie J, Keller S, Werner S, Haase H, Morano I.
Cardiovasc. Res. 2011, 90, 513–520.
PubMed

A myomesin mutation associated with hypertrophic cardiomyopathy deteriorates dimerisation properties.
Segert R, Perrot A, Keller S, Behlke J, Michalewska-Włudarczyk A, Wycisk A, Tendera M, Morano I, Ozcelik C.
Biochem. Biophys. Res. Commun. 2011, 405, 473479
PubMed

Interaction of W-substituted analogs of cyclo-RRRWFW with bacterial lipopolysaccharides: the role of the aromatic cluster in antimicrobial activity.
Bagheri M, Keller S, Dathe M.
Antimicrob. Agents Chemother. 2011, 55, 788–792.
PubMed

Short cationic antimicrobial peptides interact with ATP.
Hilpert K, McLeod B, Yu J, Elliott MR, Rautenbach M, Ruden S, Bürck J, Muhle-Goll C, Ulrich AS, Keller S, Hancock RE.
Antimicrob. Agents Chemother. 2010, 54, 4480–4483.
PubMed

Auto-inhibitory effects of an IQ motif on protein structure and function.
Petzhold D, Lossie J, Behlke J, Keller S, Haase H, Morano I. 
Biochem. Biophys. Res. Commun. 2010, 396, 939–943.
PubMed

Membrane solubilisation and reconstitution by octylglucoside: comparison of synthetic lipid and natural lipid extract by isothermal titration calorimetry.
Krylova OO, Jahnke N, Keller S.
Biophys. Chem. 2010, 150, 105–111.
PubMed

Nonlinear least-squares data fitting in Excel spreadsheets.
Kemmer G, Keller S.
Nat. Protoc. 2010, 5, 267–281.
PubMed

Crystal structures of the solute receptor GacH of Streptomyces glaucescens in complex with acarbose and an acarbose homolog: comparison with the acarbose-loaded maltose-binding protein of Salmonella typhimurium.
Vahedi-Faridi A, Licht A, Bulut H, Scheffel F, Keller S, Wehmeier UF, Saenger W, Schneider E. 
J. Mol. Biol. 2010, 397, 709–723. 
PubMed

Protein folding in membranes.
Fiedler S, Broecker J, Keller S.
Cell. Mol. Life Sci. 2010, 67, 1779–1798.
PubMed

Membrane translocation assayed by fluorescence spectroscopy.
Broecker J, Keller S. 
Methods Mol. Biol. 2010, 606, 271–289.
PubMed

Molecular basis for association of PIPKIγ-p90 with clathrin adaptor AP-2.
Kahlfeldt N, Vahedi-Faridi A, Koo SJ, Schäfer JG, Krainer G, Keller S, Saenger W, Krauss M, Haucke V.
J. Biol. Chem. 2010, 285, 2734–2749.
PubMed

α-helical transmembrane peptides: a "divide and conquer" approach to membrane proteins.
Bordag N, Keller S. 
Chem. Phys. Lipids 2010, 163, 1–26.
PubMed

Selective identification of cooperatively binding fragments in a high-throughput ligation assay enables development of a picomolar caspase-3 inhibitor.
Schmidt MF, El-Dahshan A, Keller S, Rademann J.
Angew. Chem. Int. Ed. 2009, 48, 6346–6349.
PubMed

Proline-rich sequence recognition II: proteomic analysis of Tsg101-UEV interactions.
Schlundt A, Sticht J, Piotukh K, Kosslik D, Jahnke N, Keller S, Schuemann M, Krause E, Freund C. 
Mol. Cell. Proteomics 2009, 8, 2474–2486.
PubMed

Monitoring detergent-mediated solubilization and reconstitution of lipid membranes by isothermal titration calorimetry.
Heerklotz H, Tsamaloukas AD, Keller S.
Nat. Protoc. 2009, 4, 686–697.
PubMed

Periplasmic loop P2 of the MalE subunit of the maltose ATP binding cassette transporter is sufficient to bind the maltose binding protein MalE.
Jacso T, Grote M, Daus ML, Schmieder P, Keller S, Schneider E, Reif B.
Biochemistry 2009, 48, 2216–2225.
PubMed

Uptake and release protocol for assessing membrane binding and permeation by way of isothermal titration calorimetry.
Tsamaloukas A, Keller S, Heerklotz H.
Nat. Protoc. 2007, 2, 695–704.
PubMed

A simple fluorescence-spectroscopic membrane translocation assay.
Keller S, Böthe M, Bienert M, Dathe M, Blume A.
ChemBioChem 2007, 8, 546–552.
PubMed

A network of coiled-coil associations derived from synthetic GCN4 leucine zipper arrays.
Portwich M, Keller S, Strauss HM, Mahrenholz CC, Kramer A, Kretzschmar I, Volkmer R.
Angew. Chem. Int. Ed. 2007, 46, 1654–1657.
PubMed

Caged capsaicins: new tools for the examination of TRPV1 channels in somatosensory neurons.
Gilbert D, Funk K, Lechler R, Keller S, Möhrlen F, Frings S, Hagen V.
ChemBioChem 2007, 8, 89–97.
PubMed

Dipalmitoylation of a cellular uptake-mediating apolipoprotein E-derived peptide as a promising modification for stable anchorage in liposomal drug carriers.
Sauer I, Nikolenko H, Keller S, Abu Ajaj K, Bienert M, Dathe M.
Biochim. Biophys. Acta 2006, 1758, 552–561.
PubMed

Thermodynamics of lipid membrane solubilization by sodium dodecyl sulfate.
Keller S, Heerklotz H, Jahnke N, Blume A.
Biophys. J. 2006, 90, 4509–4521.
PubMed

A caged doxycycline analogue for photoactivated gene expression.
Cambridge SB, Geissler D, Keller S, Cürten B.
Angew. Chem. Int. Ed. 2006, 45, 2229–2231.
PubMed

Monitoring lipid membrane translocation of sodium dodecyl sulfate by isothermal titration calorimetry.
Keller S, Heerklotz H, Blume A.
J. Am. Chem. Soc. 2006, 128, 1279–1286.
PubMed

Coumarinylmethyl esters for ultrafast release of high concentrations of cyclic nucleotides upon one- and two-photon photolysis.
Hagen V, Dekowski B, Nache V, Schmidt R, Geissler D, Lorenz D, Eichhorst J, Keller S, Kaneko H, Benndorf K, Wiesner B.
Angew. Chem. Int. Ed. 2005, 44, 7887–7891.
PubMed

A quantitative model describing the selective solubilization of membrane domains.
Keller S, Tsamaloukas A, Heerklotz H. 
J. Am. Chem. Soc. 2005, 127, 11469–11476. 
PubMed

A critical reassessment of penetratin translocation across lipid membranes.
Bárány-Wallje E, Keller S, Serowy S, Geibel S, Pohl P, Bienert M, Dathe M.
Biophys. J. 2005, 89, 2513–2521.
PubMed

Membrane-mimetic nanocarriers formed by a dipalmitoylated cell-penetrating peptide.
Keller S, Sauer I, Strauss H, Gast K, Dathe M, Bienert M.
Angew. Chem. Int. Ed. 2005, 44, 5252–5255.
PubMed

(Coumarin-4-yl)methyl esters as highly efficient, ultrafast phototriggers for protons and their application to acidifying membrane surfaces.
Geissler D, Antonenko YN, Schmidt R, Keller S, Krylova OO, Wiesner B, Bendig J, Pohl P, Hagen V.
Angew. Chem. Int. Ed. 2005, 44, 1195–1198.
PubMed

Book Chapters

Peptide–membrane interactions studied by isothermal titration calorimetry.
Klingler J, Keller S.
In Biocalorimetry: Foundations and Contemporary Approaches
Bastos M, Ed.; CRC Press: London, 2015, in print.

Pharmacological interference with protein–protein interactions mediated by coiled-coil motifs.
Strauss HM, Keller S.
In Handbook of Experimental Pharmacology 186: Protein–Protein Interactions as New Drug Targets
Klussmann E, Scott J, Eds.; Springer-Verlag: Berlin, 2008, 461–481.

Cellular uptake of liposomal and micellar carriers mediated by apoE-derived peptides.
Dathe M, Keller S, Sauer I, Bienert M.
In Handbook of Cell-Penetrating Peptides 2nd ed. Langel Ü, Ed.; CRC Press: Boca Raton, 2006, 483–503.

Patent

Peptide and protein affinity tag.
Keller S, Bordag N.
EP 10 075 359.9, US 61/376,083; deposited 23rd August 2010.