Division of Nanophysiology

Peer-reviewed Data Articles

2020

López-Hernández T, Puchkov D, Krause D, Maritzen T, Haucke V. Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis. Nat Cell Biol. 2020 Jun 29. doi: 10.1038/s41556-020-0535-7.

Gowrisankaran S, Houy S, Del Castillo JGP, Steubler V, Gelker M, Kroll J, Pinheiro PS, Schwitters D, Halbsgut N, Pechstein A, van Weering JRT, Maritzen T, Haucke V, Raimundo N, Sørensen JB, Milosevic I. Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin. Nat Commun. 2020 Mar 9;11(1):1266. doi: 10.1038/s41467-020-14993-8

Kroll J, Oezcete OD, Jung S, Maritzen T, Milosevic I, Wichmann C, Moser T. AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells. J Cell Sci. 2020 Jan 22;133(2). pii: jcs236737. doi: 10.1242/jcs.236737.

Jaepel M, Gerth F, Sakaba T, Bacetic J, Yao L, Koo SJ, Maritzen T, Freund C, Haucke V. Intersectin-mediated clearance of SNARE complexes is required for fast neurotransmission. Cell Rep. 2020 Jan 14;30(2):409-420.e6. doi: 10.1016/j.celrep.2019.12.035

2019

Jaepel M, Gerth F, Sakaba T, Bacetic J, Yao L, Koo SJ, Maritzen T, Freund C, Haucke V. Intersectin-mediated clearance of SNARE complexes is required for fast neurotransmission. Cell Rep. 2020 Jan 14;30(2):409-420.e6. doi: 10.1016/j.celrep.2019.12.035

Maglione M, Kochlamazashvili G, Eisenberg T, Racz B, Michael E, Toppe D, Stumpf A, Wirth A, Zeug A, Müller F, Moreno-Velasquez L, Sammons R, Hofer S, Madeo F, Maritzen T, Maier N, Ponimaskin E, Schmitz D, Haucke V, Sigrist SJ. Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses. Sci Rep. 2019 Dec 23;9(1):19616. doi: 10.1038/s41598-019-56133-3

Fred SM, Laukkanen L, Brunello CA, Vesa L, Göös H, Cardon I, Moliner R, Maritzen T, Varjosalo M, Casarotto PC, Castrén E. Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endoctic adaptor complex AP-2. J Biol Chem. 2019 Oct 20. pii: jbc.RA119.008837. doi: 10.1074/jbc.RA119.008837

Pascolutti* R, Algisi* V, Conte A, Raimond A, Pasham M, Upadhyayula S, Maritzen T, Gaudin R, Barbieri E, Caldieri G, Freddi S, Confalonieri S, Malabarba MG, Maspero E, Polo S, Tacchetti C, Haucke V, Kirchhausen T, Di Fiore PP, Sigismund S. Molecularly distinct clathrin-coated pits differentially impact on EGFR fate and signaling. Cell Rep. 2019 Jun 4;27(10):3049-3061
  

2017

Gerth* F, Jäpel* M, Pechstein* A, Kochlamaszashvili G, Lehmann M, Puchkov D, Onofri F, Benfenati F, Nikonenko AG, Maritzen T, Freund C, Haucke# V. Intersectin associates with synapsin and regulates its nanoscale localization and function. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):12057-12062

Mertins P, Przybylski D, Yosef N, Qiao J, Clauser K, Raychowdhury R, Eisenhaure TM, Maritzen T, Haucke V, Satoh T, Akira S, Carr SA, Regev A, Hacohen N, Chevrier N. An integrative framework reveals signaling-to-transcription events in Toll-like receptor signaling. Cell Rep. 2017 Jun 27;19(13):2853-2866

Jakob B, Kochlamazashvili G, Jäpel M, Gauhar A, Bock H, Maritzen T, Haucke V. Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus. Proc Natl Acad Sci U S A. 2017 May 23;114(21):5533-5538

Kononenko NL, Claßen GA, Kuijpers M, Puchkov D, Maritzen T, Tempes A, Malik AR, Skalecka A, Bera S, Jaworski J, Volker Haucke. Retrograde transport of TrkB-containing autophagosomes via the endocytic adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration. Nat Commun. 2017; 8:14819
  

2015

Schachtner* H, Weimershaus* W, Stache V, Plewa N, Legler DF, Höpken UE, Maritzen T. Loss of Gadkin affects dendritic cell migration in vitro. PLOS ONE. 2015; 10(12):e0143883

Feutlinske* F, Browarski* M, Ku M, Trnka P, Waiczies S, Niendorf T, Stallcup WB, Glass R, Krause E, Maritzen T. Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility. Nat Commun. 2015; 6:8535

Jung* SY, Maritzen* T, Wichmann* C, Jing Z, Neef A, Revelo NH, Al-Moyed H, Meese S, Wojcik SM, Panou I, Bulut H, Schu P, Ficner R, Reisinger E, Rizzoli SO, Neef J, Strenzke N, Haucke V, Moser T. Disruption of adaptor protein 2µ (AP-2µ) in cochlear hair cells impairs synaptic vesicle replenishment and hearing. EMBO J. 2015; 34(21):2686-702

Koo* SJ, Kochlamazashvili* G, Rost B, Puchkov D, Gimber N, Lehmann M, Tadeus G, Schmoranzer J, Rosenmund C, Haucke# V, Maritzen# T. Vesicular synaptobrevin/VAMP2 levels guarded by AP180 control efficient neurotransmission. Neuron. 2015; 88(2):330-44

Gimber N, Tadeus G, Maritzen T, Schmoranzer J, Haucke V. Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins. Nat Commun. 2015; 6:8392

Kaempf N, Kochlamazashvili G, Puchkov D, Maritzen T, Bajjalieh SM, Kononenko NL, Haucke V. Overlapping functions of stonin 2 and SV2 in sorting of the calcium sensor synaptotagmin 1 to synaptic vesicles. Proc Natl Acad Sci U S A. 2015; 112(23):7297-302

Seifert W, Kühnisch J, Maritzen T, Lommatzsch S, Hennies HC, Bachmann S, Horn D, Haucke V. Cohen Syndrome-associated Protein COH1 Physically and Functionally Interacts with the Small GTPase RAB6 at the Golgi Complex and Directs Neurite Outgrowth. J Biol Chem. 2015; 290(6):3349-58

Pechstein A, Gerth F, Milosevic I, Jäpel M, Eichhorn-Grünig M, Vorontsova O, Bacetic J, Maritzen T, Shupliakov O, Freund C, Haucke V. Vesicle uncoating regulated by SH3-SH3 domain-mediated complex formation between endophilin and intersectin at synapses. EMBO Rep. 2015; 16(2):232-9
  

2014

Kononenko NL, Puchkov D, Classen GA, Walter AM, Pechstein A, Sawade L, Kaempf N, Trimbuch T, Lorenz D, Rosenmund C, Maritzen T, Haucke V. Clathrin/AP-2 mediate synaptic vesicle reformation from endosome-like vacuoles but are not essential for membrane retrieval at central synapses. Neuron. 2014; 82(5):981-8
  

2013

Kononenko N, Diril MK, Puchkov D, Kintscher M, Koo SJ, Pfuhl G, Winter Y, Wienisch M, Klingauf J, Breustedt J, Schmitz D, Maritzen*# T, Haucke*# V. Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2. Proc Natl Acad Sci U S A. 2013;110(6):526-35
  

2012

Maritzen T, Zech T, Schmidt MR, Krause E, Machesky LM, Haucke# V. Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. Proc Natl Acad Sci U S A. 2012; 109(26):10382-7
  

2011

Seifert W, Kuehnisch J, Maritzen T, Horn H, Haucke V, Hennies HC. The Cohen syndrome-associated protein, COH1, is a novel, giant Golgi matrix protein required for Golgi integrity. J Biol Chem. 2011; 286(43):37665-75

Koo SJ, Markovic S, Puchkov D, Mahrenholz CC, Beceren-Braun F, Maritzen T, Dernedde J, Volkmer R, Oschkinat H, Haucke V. SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses. Proc Natl Acad Sci U S A. 2011; 108(33):13540-5

Laulagnier K, Schieber NL, Maritzen T, Haucke V, Parton RG, Gruenberg J. Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes. Mol Biol Cell. 2011; 22(12):2068-8
  

2010

Maritzen* T, Schmidt* MR, Kukhtina V, Higman V, Strauss H, Volkmer R, Oschkinat H, Dotti CG, and Haucke V. A novel subtype of AP-1 binding motif within the palmitoylated TGN/endosomal accessory protein Gadkin/g-BAR. J Biol Chem. 2010; 285(6):4074-86
  

2009

Schmidt* MR, Maritzen* T, Kukhtina V, Higman VA, Doglio L, Barak NN, Strauss HM, Oschkinat H, Dotti CG, Haucke V. Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex. Proc Natl Acad Sci U S A. 2009; 106(36):15344-
  

2008

Maritzen T, Keating DJ, Neagoe I, Zdebik AA, Jentsch TJ. Role of the vesicular chloride transporter ClC-3 in neuroendocrine tissue. J Neurosci. 2008; 28(42):10587-98

Rumpf J, Simon B, Jung N, Maritzen T, Haucke V, Sattler M, Groemping Y. Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity. EMBO J. 2008; 27(3):558-69
  

2006

Maritzen* T, Lisi* S, Botta R, Pinchera A, Fanelli G, Viacava P, Marcocci C, Marinò M. ClC-5 Does Not Affect Megalin Expression and Function in the Thyroid. Thyroid. 2006; 16(8):725-30

Maritzen* T, Rickheit* G, Schmitt A, Jentsch TJ. Kidney-specific upregulation of vitamin D3 target genes in ClC-5 KO mice. Kidney Int. 2006; 70(1):79-87

Rust MB, Faulhaber J, Budack MK, Pfeffer C, Maritzen T, Didié M, Beck FX, Boettger T, Schubert R, Ehmke H, Jentsch TJ, Hübner CA. Neurogenic mechanisms contribute to hypertension in mice with disruption of the K-Cl cotransporter KCC3. Circ Res. 2006; 98(4):549-5
  

2003

Maritzen T, Löhler J, Deppert W, Knippschild U. Casein kinase I delta is involved in lymphocyte physiology. Eur J Cell Biol. 2003; 82(7):369-78

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