Division of Human Biology

List of Publications

Simone Eggert

Publications Kins lab, Kaiserslautern

1. Eggert, S., Kins, S., Endres, K., Brigadski, T., Brothers in arms: proBDNF/BDNF and sAPPα/Aβ signaling and their common interplay with ADAM10, TrkB, p75NTR, sortilin, and sorLA in the progression of Alzheimer`s disease. Biol.Chem 2021 Oct 7. doi: 10.1515/hsz-2021-0330. Online ahead of print. Review. 

2. Witthohn, M., Strieth, D, Eggert, S., Kins., S, Ulber, R., Muffler, K. Heterologous production of a cyanobacterial bacteriocin with potent antibacterial activityCurrent Research in Biotechnology, accepted, 03.11.2021 

3. Nguyen VTT, König S, Eggert S, Endres K, Kins S The role of mycotoxins in neurodegenerative diseases: current state of the art and future perspectives of research.Biol Chem. 2021 Aug 27. doi: 10.1515/hsz-2021-0214. Online ahead of print. 

4. In revision: Marz, SA., Jan A. Kullmann, JA, Mattson S. O. Jones, MSO., Fecher-Trost, C., Jung, M., Alexander, RT., Eggert, S. & Friauf. E., Interactome of Glycine transporter 2: CAPS1 regulates GlyT2 activity by promoting endocytosis. JBC, IF 2020: 5.1

5. Endres, K and Eggert, S, Presentation of Scientific Institutions, “NeurodegX” Neuroforum (De Gruyter), 25.07.2020 https://doi.org/10.1515/nf-2020-0019

6. Eggert, S.*, Grübl, T.*, Rupp, C., Sander, B., Heesch, A., Rajender, R., Zimmermann, M., Höpfner, S., Zentgraf, H., Kins, S., The Rab5 activator RME-6 is required for Amyloid Precursor Protein (APP) endocytosis depending on the juxtamembranous YTSI motif, Cell Mol Life Sci 2020 Dec;77(24):5223-5242. doi: 10.1007/s00018-020-03467-1. Epub 2020 Feb 17

7. August A, Schmidt N, Klingler J, Baumkötter F, Lechner M, Klement J, Eggert S, Vargas C, Wild K, Keller S, Kins S., Copper and zinc ions govern the trans-directed dimerization of APP family members in multiple ways. J Neurochem 2019 May 7. 151(5):626-641 doi: 10.1111/jnc.14716. Epub 2019 Jun 6

8. Eggert, S., Kins, S., Thomas, C., Hermey, G, Trafficking in Alzheimer’s disease: Modulation of APP transport and processing by the transmembrane proteins LRP1, SorLA, SorcS1c, Sortilin and Calsyntenin, Mol Neurobiol. 2018 Jul;55(7):5809-5829. doi: 10.1007/s12035-017-0806-x. Epub 2017 Oct 27. Review.

9. Eggert, S.,* Gonzalez, AC.,* Thomas, C., Schwarz, SM., Tischer, C., Schilling, S., Strecker, P., Schmidt, V., Willnow, TE., Hermey, G., Pietrzik, CU., Koo, EH, Kins, S. Dimerization leads to changes in APP (Amyloid Precursor Protein) trafficking mediated by LRP1 and SorLA, Journal of Cellular and Molecular Life Sciences, 2018 Jan;75(2):301-322. doi: 10.1007/s00018-017-2625-7. Epub 2017 Aug 10. PMID:28799085

10. Feilen, LP., Haubrich, K., Strecker, P., Probst, S., Eggert, S., Stier, G., Sinning, I., Konietzko, U., Kins, S., Simon, B., Wild, K., Fe65-PTB2 dimerization mimics Fe65-APP interaction, Front Mol Neurosci, 2017 May 11;10:140. doi: 10.3389/fnmol.2017.00140. eCollection.

11. Herr, U.M.*, Strecker, P*., Storck, S., Thomas, C., Rabiej, V., Junker, A., Schilling, S., Schmidt, N., Dowds, M., Eggert, S., Pietrzik, CU., Kins, S. LRP1 recruits APP to anterograde and retrograde transport vesicles and affects its processing in the mono- and dimeric state, Front Mol Neurosci, 2017 Apr 27;10:118, doi: 10.3389/fnmol.2017.00118. eCollection 2017

12. Schilling, S.,* Mehr, A.,*, Ludewig, S., Stephan, J., Zimmermann, M., August, A., Strecker, P., Korte, M., Koo, EH., Müller, U.,*, Kins, S.,*, Eggert, S.* Synaptic Cell adhesion molecule APLP1 is required for maintenance of dendritic spines and basal synaptic transmission J Neurosci  2017 May 24;37(21):5345-5365. doi: 10.1523/JNEUROSCI.1875-16.2017. Epub 2017 Apr 27

13. Stahl, R., Schilling, S., Soba, P., Rupp, C., Hartmann, T., Wagner, K., Merdes, G., Eggert, S.* and Kins, S.* Shedding of the Amyloid precursor protein limits its synaptogenic and cell adhesion activity Front Cell Neurosci 2014 Dec 03; 3;8:410doi: 10.3389/fncel.2014.00410. eCollection 2014.

14. Baumkotter, F., Schmidt, N., Vargas, C., Schilling, S., Weber, R., Wagner, K., Fiedler, S., Klug, W., Radzimanowski, J., Keller, S., Eggert, S., Wild, K., and Kins, S. "Amyloid Precursor Protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain" J Neurosci 2014 Aug 13;34(33):11159-72

15. Thyrock, A., Ossendorf, E., Stehling, M., Kail, M., Kurtz, T., Pohlentz, G., Waschbüsch, D., Eggert, S., Formstecher, E., Müthing, J., Dreisewerd, K., Kins, S., Goud, B., Barnekow, A. A New Mint1 Isoform, but Not the Conventional Mint1, Interacts with the Small GTPase Rab6. PLoS One 2013 8(5):e64149

16. Isbert, S., Wagner, K., Eggert, S., Schweitzer, A., Multhaup, G., Weggen, S., Kins, S., Pietrzik, CU. APP dimer formation is initiated in the endoplasmatic reticulum and differs between APP isoforms. Cell Mol Life Sci 2012 Apr;69(8):1353-75

17. Baumkotter, F., Wagner, K., Eggert, S., Wild, K., Kins, S. Structural aspects and physiological consequences of APP/APLP trans-dimerization. Exp Brain Res 2012 Apr;217(3-4):389-95

Publications Koo lab, San Diego

18.  Nagahara, A.H., Mateling, M., Kovacs, I., Wang, L., Eggert, S., Rockenstein, E., Koo, EH., Masliah, E., Tuszynski., M.H. Early BDNF Treatment Ameliorates Cell Loss in the Entorhinal Cortex of APP Transgenic Mice, J Neurosci 2013 Sep 25;33(39):15596-602

19.  Jung, HJ., Kim, YJ., Eggert,S., Chung, KC., Choi, KS., Park SA. Age-dependent increases in tau phosphorylation in the brains of type 2 diabetic rats correlate with a reduced expression of p62. Exp Neurol2013 Jul 29;248C:441-450

20.  Tyan, SH., Shih, AY., Walsh, JJ., Maruyama, H., Sarsoza, F., Ku, L., Eggert,S., Hof, PR., Koo, EH., Dickstein, DL. Amyloid precursor protein (APP) regulates synaptic structure and function. Mol and Cell Neurosci2012 51(1-2):43-52

21.  Midthune, B., Tyan, SH., Walsh, JJ., Sarsoza, F., Eggert, S., Hof, PR., Dickstein, DL., Koo, EH. Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function. Mol and Cell Neurosci2012 49(4):448-55

22.  Kukar, TL., Ladd, TB., Robertson, P., Pintchovski, SA., Moore, B., Bann, MA., Ren, Z., Jansen-West, K., Malphrus, K., Eggert, S., Maruyama, H., Cottrell, BA., Das, P., Basi, GS., Koo, EH., Golde, TE. Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region. J Biol Chem2011 286(46), 39804-12

23.  Eggert, S., Midthune, B., Cottrell, B., Koo, E.H. Induced dimerization of APP leads to decreased Amyloid-β protein (Aβ) production. J Biol Chem2009 284(42), 28943-52

Publications Beyreuther lab, Heidelberg

24.  Kuan, YH., Gruebl, T., Soba, P., Eggert, S., Nesic, I., Back, S., Kirsch, J., Beyreuther, K., Kins, S. PAT1a modulates intracellular transport and processing of APP, APLP1 and APLP2. J Biol Chem 2006 281(52). 40114-23

25.  Soba, P., Eggert, S., Wagner, K., Zentgraf, H., Siehl, K., Kreger, S., Loewer, A., Langer, A., Merdes, G., Paro, R., Masters, CL., Mueller, U., Kins, S., and Beyreuther, K. Homo- and Heterodimerization of APP family members promotes intercellular adhesion. The EMBO Journal 2005 24(20), 3624-3634         

26.  Eggert, S., Paliga, K., Soba, P., Evin, G. Masters, C.L., Weidemann, A., and Beyreuther, K. The proteolytic processing of the Amyloid Precursor Protein gene family members APLP-1 and APLP-2 involves α-, β-, γ- and ε-like cleavages. Modulation of APLP-1 processing by glycosylation. J Biol Chem2004 279(18), 18146-56

27.  Walsh, DM., Fadeeva, JV., LaVoie, MJ., Paliga, K., Eggert, S., Kimberly, WT., Wasco, W., Selkoe, DJ. Gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry 2003 42(22), 6664-73

28.  Evin, G., Holsinger, D.R.M., Eggert, S., Weidemann, A., Canterford, L., Hoke, D., Gandy, S., McLean, C., Beyreuther, K., and Masters, C.L. Carboxyl-Terminal Fragments of the Amyloid Precursor Protein in Alzheimer’s Disease Brain: Detection of γ-Secretase Products. Brain Aging 2002 2, 61-66

29.  Weidemann, A., Eggert, S., Reinhard, F.B.M., Vogel, M., Paliga, K., Baier,G., Masters, C.L., Beyreuther,K., and Evin, G. A novel ε-Cleavage within the Transmembrane Domain of the Alzheimer Amyloid Protein Demonstrates Homology with Notch Processing. Biochemistry 2002 41(8), 2825-2835



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