Fachgebiet Humanbiologie

List of Publications

Stefan Kins


2019

Konietzko U, Gersbacher MT, Streuli J, Krüger M, Thöni S, Kins S, Nitsch RM. A fluorescent    protein-readout for transcriptional activity reveals regulation of APP nuclear signaling by phosphorylation sites. Biol Chem. 2019 May 1. pii: /j/bchm.just-accepted/hsz-2019-0125/hsz-2019-0125.xml. doi: 10.1515/hsz-2019-0125. [Epub ahead of print]

Hermey G, Hoffmeister-Ullerich SA, Merz B, Groß D, Kuhl D, Kins S. Amyloidosis causes downregulation of SorLA, SorCS1 and SorCS3 expression in mice. Biol Chem. 2019 May 16. pii: /j/bchm.ahead-of-print/hsz-2019-0146/hsz-2019-0146.xml. doi: 10.1515/hsz-2019-0146. [Epub ahead of print]

August A, Schmidt N, Klingler J, Baumkötter F, Lechner M, Klement J, Eggert S, Vargas C, Wild K, Keller S, Kins S., Copper and zinc ions govern the trans-directed dimerization of APP family members in multiple ways. J Neurochem. 2019 May 7. doi: 10.1111/jnc.14716. [Epub ahead of print]

Hollnagel JO, Elzoheiry S, Gorgas K, Kins S, Beretta CA, Kirsch J, Kuhse J, Kann O, Kiss E. (2019) Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer's disease amyloidosis. PLoS One 14:e0209228.

2018

Eggert S, Thomas C, Kins S, Hermey G. (2018) Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin. Mol Neurobiol 55: 5809-29.

Eggert S, Gonzalez AC, Thomas C, Schilling S, Schwarz SM, Tischer C, Adam V, Strecker P, Schmidt V, Willnow TE, Hermey G, Pietrzik CU, Koo EH, Kins S (2018) Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA. Cell Mol Life Sci. 75: 301-22.

2017

Feilen LP, Haubrich K, Strecker P, Probst S, Eggert S, Stier G, Sinning I, Konietzko U, Kins S, Simon B, Wild K (2017) Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction. Front Mol Neurosci 10:140.

Herr UM, Strecker P, Storck SE, Thomas C, Rabiej V, Junker A, Schilling S, Schmidt N, Dowds CM, Eggert S, Pietrzik CU, Kins S (2017) LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State. Front Mol Neurosci 10:118.

Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller UC, Kins S*, Eggert S* (2017) APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission. J Neurosci 37: 5345-5365. *contributed equally

Guénette S, Strecker P, Kins S (2017) APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins. Front Mol Neurosci 10:87.

Wild K, August A, Pietrzik CU, Kins S. (2017) Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments. Front Mol Neurosci 10:21.

2016

Kundu A, Milosch N, Antonietti P, Baumkötter F, Zymny A, Müller UC, Kins S, Hajieva P, Behl C, Kögel D (2016) Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP. Mol Neurobiol. 53: 5985-94

Strecker P, Ludewig S, Rust M, Mundinger TA, Görlich A, Krächan EG, Mehrfeld C, Herz J, Korte M, Guénette SY and Kins S (2016) FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation. Sci Reports 6: 25652

Kiss E, Gorgas K, Schlicksupp A, Groß D, Kins S, Kirsch J, Kuhse J (2016) Biphasic Alteration of the Inhibitory Synapse Scaffold Protein Gephyrin in Early and Late Stages of an Alzheimer Disease Model. Am J Pathol. S0002-9440: 30208-5

Morfini G, Schmidt N, Weissmann C, Pigino G, Kins S (2016) Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease. Brain Res Bull. 126: 347-353

2015

Hermey G, Schmidt N, Bluhma B, Menschinga D, Ostermann K, Rupp C, Kuhl D and Kins S (2015) SorCS1 variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCS1c modulates anterograde APP transport, J Neurochem, 135:60-75

Renziehausen J, Hiebel C, Nagel H, Kundu A, Kins S, Kögel D, Behl C, Hajieva P. (2015) The Cleavage Product of Amyloid-β Protein Precursor sAβPPα Modulates BAG3-Dependent Aggresome Formation and Enhances Cellular Proteasomal Activity. J Alzheimers Dis. 44: 879-96

2014

Stahl R, Schilling S, Soba P, Rupp C, Hartmann T, Wagner K, Merdes G, Eggert S and Kins S (2014) Shedding of APP limits its synaptogenic activity and cell adhesion properties. Front Cell Neurosci 8: e410

Milosch N, Tanriöver G, Kundu A, Rami A, François JC, Baumkötter F, Weyer SW, Samanta A, Jäschke A, Brod F, Buchholz CJ, Kins S, Behl C, Müller UC, Kögel D. (2014) Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway. Cell Death Dis, 5: e1391

Rupp C, Beyreuther K, Maurer K and Kins S (2014) A presenillin1 mutation in the first case of Alzheimer’s disease: revisited. Alzheimers Dement, 10: 869-72

Baumkötter F, Schmidt N, Vargas C, Schilling S, Weber R, Wagner K, Fiedler S, Klug W, Radzimanowski J, Nickolaus S, Keller S, Eggert S, Wild K and Kins S (2014) Amyloid Precursor Protein dimerization and synaptogenic function depend on copper binding to the growth factor like domain. J Neurosci 34: 11159-72

Klevanski M, Saar M, Baumkötter F, Weyer SW, Kins S, Müller UC. (2014) Differential role of APP and APLPs for neuromuscular synaptic morphology and function. Mol Cell Neurosci 61: 201-10

2013

Thyrock A, Ossendorf E, Stehling M, Kail M, Kurtz T, Pohlentz G, Waschbüsch D, Eggert S, Formstecher E, Müthing J, Dreisewerd K, Kins S, Goud B, Barnekow A. (2013) A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6. PLoS One 8: e64149

Riemer J, Kins S. (2013) Axonal Transport and Mitochondrial Dysfunction in Alzheimer's Disease. Neurodegener Dis 12: 111-24

2012

Grimm MO, Rothhaar TL, Grösgen S, Burg VK, Hundsdörfer B, Haupenthal VJ, Friess P, Kins S, Grimm HS, Hartmann T. (2012) Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP). J Nutr Biochem 23: 1214-23

Isbert S, Wagner K, Eggert S, Schweitzer A, Multhaup G, Weggen S, Kins S, Pietrzik CU. (2012) APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms. Cell Mol Life Sci 69: 1353-75

Brunholz S, Sisodia S, Lorenzo A, Deyts C, Kins S, Morfini G. (2012) Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells. Exp Brain Res 217: 353-64

Baumkötter F, Wagner K, Eggert S, Wild K, Kins S. (2012) Structural aspects and physiological consequences of APP/APLP trans-dimerization. Exp Brain Res 217: 389-95

2009

Szodorai A, Kuan YH, Hunzelmann S, Engel U, Sakane A, Sasaki T, Takai Y, Kirsch J, Müller U, Beyreuther K, Brady S, Morfini G, Kins S (2009) APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. J Neurosci 29: 14534-14544.

2008

DeBoer S, You Y, Szodorai S, Kaminska A, Pigino G, Nwabuisi E, Estrada-Hernandez T, Kins S, Brady ST and Morfini G (2008) Conventional Kinesin is Composed of Kinesin Heavy and Light Chain homodimers. Biochemistry 47: 4535-43.

Kins S and Beyreuther K (2008) Alzheimer’s Disease. In: „Encyclopedia of Molecular Mechanisms of Disease“, Springer Verlag.

2007

Back S, Haas P, Tschäpe JA, Gruebl T, Kirsch J, Müller U, Beyreuther K, Kins S (2007) In neurons APP can be transported independent of any sorting signal to the axonal and dendritic compartment. J Neurosci Res 25: 1079-86

Rusu P, Jansen A, Soba P, Kirsch J, Löwer A, Merdes G, Kuan Y-H, Jung A, Beyreuther K, Kjaerulff O, Kins S (2007) Axonopathy in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity, Eur J Neurosci 25: 1079-86

2006

Kuan Y-H, Grübl T, Soba P, Eggert S, Nesic I, Kirsch J, Beyreuther K, Kins S (2006) The processing and anterograde transport of APP, APLP1 and APLP2 is affected by the carboxyl-terminal binding partner PAT1a. J Biol Chem 281: 40114-123.

Kins S, Lauther N, Szodorai A, and Beyreuther K (2006) Subcellular trafficking of the APP gene family and its pathogenic role in Alzheimer’s Disease. Neurodegener Dis 3: 218-26.

Kins S, Beyreuther K (2006) Teasing out the tangles. Nature Med 12: 764-5.

Götz J, Ittner LM, and Kins, S (2006) Do axonal defects in tau and APP transgenic animals model axonopathy in Alzheimer’s disease? J Neurochem 98: 993-1006.

Horster F, Schwab MA, Sauer SW, Pietz J, Hoffmann GF, Okun JG, Kolker S, Kins S (2006) Phenylalanine reduces synaptic density in mixed cortical cultures from mice. Pediatr Res 59: 544-48.

2005

Soba P, Eggert S, Zentgraf H, Kreger S, Löwer A, Merdes G, Paro R, Masters CL, Müller U, Kins S*, Beyreuther K* (2005) Cell interactions are promoted by trans-dimerization of APP family members, arranged as homo- or hetero-complexes in synaptic membranes. EMBO J 24: 3624-36. *These two authors contributed equally

von Rotz RC, Kins S, Hipfel R, von der Kammer H, Nitsch RM (2005) The cytosolic ring finger protein dactylidin is selectively upregulated in brains of patients with Alzheimer’s disease. Eur J Neurosci 21: 1289-98.

Lazarov O, Morfini GA, Szodorai A, Kins S, Lee V, Trojanowski J, Price D, Brady ST, Sisodia SS (2005) Axonal Transport, APP, Kinesin and the Processing Apparatus: Revisited. J Neurosci 25: 2386-95.

2003

Kins S, Kurosinski P, Nitsch RM and Götz J (2003) Hyperphosphorylation and somatodendritic localization of tau in PP2A dominant negative mutant mice is associated with activation of ERK and JNK signaling. J Am Path 163: 833-843.

Chen F, Ferrari A, Schild A, Kurosinski P, David D, Hoerndli F, Pennanen L, Kins S, van Dorpe J, Nitsch RM, Götz J (2003) Amyloid-induced neurofibrillary tangle formation. In: Alzheimer‚s disease and related disorders: Research advances (editors: K. Iqbal, B. Winblad; Ana Aslan International Foundation)

2002

Schmidt K, Kins S, Schild A, Nitsch RM, Hemmings B and Gotz J (2002) Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A. Eur J Neurosci 16: 2039-48.

Fuhrmann JC, Kins S, Kirsch J, Kneussel M, Betz H (2002) Gephyrin interacts with DLC-1/PIN and DLC-2, components of the cytoplasmic dynein complex. J Neurosci 22: 5393-402.

Müller U and Kins S (2002) APP on the move. Trends Mol Med. 8: 152-5.

2001

Steinhoff T, Moritz E, Wollmer MA, Mohajeri MH, Kins S and Nitsch RM (2001) Increased cystatin C in astrocytes of transgenic mice expressing the K670N-M671L mutation of the amyloid precursor protein and deposition in brain amyloid plaques. Neurobiol Dis 8: 647-54.

Kins S, Crameri A, Evans DR, Hemmings BA, Nitsch RM, and Gotz J (2001) Reduced PP2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. J Biol Chem 276: 38193-200.

2000

Grosskreutz Y, Hermann A, Kins S, Fuhrmann JC, Betz H, and Kneussel M (2000) Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin. Biol Chem  382: 1455-62.

Ramming M, Kins S, Werner N, Hermann A, Betz H, and Kirsch J (2000) Diversity and phylogeny of gephyrin: tissue-specific splice variants, gene structure, and sequence similarities to molybdenum cofactor-synthesizing and cytoskeleton-associated proteins. Proc Natl Acad Sci U S A 97: 10266-71.

Kins S, Betz H, and Kirsch J (2000) Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin. Nature Neurosci 3: 22-29.

1999

Kins S, Kuhse J, Laube B, Betz H and Kirsch J (1999) Incorporation of a gephyrin-binding motif targets NMDA receptors to gephyrin-rich domains in HEK 293 cells. Eur J Neurosci 11: 740-4

Zum Seitenanfang