Zur Hauptnavigation / To main navigation

Zur Sekundärnavigation / To secondary navigation

Zum Inhalt dieser Seite / To the content of this page

Hauptnavigation / Main Navigation

Sekundärnavigation / Secondary navigation

Inhaltsbereich / Content

Publikationen

 

Eggert, S., Thomas, C., Kins, S., Hermey, G., (2017) Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin and Calsyntenin. Mol Neurobiol. doi: 10.1007/S12035-017-0806-x

 

Eggert, S.*, Gonzalez, A.C.*, Thomas, C., Schilling, S., Schwarz, S.M., Tischer, C., Adam, V., Strecker, P., Schmidt, V., Willnow, T.E., Hermey, G., Pietrzik, C.U., Koo, E.H., Kins, S., (2017) Dimerziation leads to changes in APP (Amyloid Precursor Protein) trafficking mediated by LRP1 and SorLA. Journal of Cellular and Molecular Life Scienc: DOI 10.1007/s00018-017-2625-7

 

Feilen, L., Haubrich, K., Strecker, P., Probst, S., Eggert, S., Sinning, I., Konietzko, U., Kins, S., Simon, B., Wild, K., (2017) Fe65-PTB2 dimerization mimics Fe65-APP interaction and regulates APP function. Front Mol Neurosci: 10:140

 

Herr, U.-M.*, Strecker, P.*, Storck, S.E., Thomas, C., Rabiej, V., Junker, A., Schilling, S., Schmidt, N., Dowds, C.M., Eggert, S., Pietrzik, C.U., Kins, S., (2017) LRP1 Modulates APP Intraneuronal Transport and Processing in its Monomeric and Dimeric State. Front Mol Neurosci: 10:118

 

Schilling, S.*, Mehr, A.*, Ludewig, S., Stephan, J., Zimmermann, M., August, A., Strecker, P., Korte, M., Koo, E.H., Müller, U.C.*, Kins, S.*, Eggert, S.*, (2017) APLP1 is a synaptic cell adhesion molecule, supporting maintenance of dendritic spines and basal synaptic transmission. J Neurosci: 37:5345

 

Guénette, S., Strecker, P., Kins, S., (2017) APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins. Front Mol Neurosci: 10:87

 

Wild, K., August, A., Pietrzik, C.U., Kins, S., (2017) Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments, Front ol Neurosci: 10:21

 

Morfini, G., Schmidt, N., Weissman, C., Pigino, G., Kins, S., (2016) Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease. Brain Res Bull doi: 10.1016/j.brainresbull.2016.06.009

 

Strecker, P., Ludewig, S., Rust, M., Mundinger, TA., Görlich, A., Krächan, EG., Mehrfeld, C., Herz, J., Korte, M., Guénette SY., Kins, S., (2016) FE65 and FE65L1 share common synaptic functions and genetcally interact with the APP family in neuromuscular junction formation. Sci Reports 6: 25652

 

Kiss, E., Gorgas, K., Schlicksupp, A., Groß, D., Kins, S., Kirsch, J., Kuhse, J., (2016) Biphasic alteration of the inhibitory synapse scaffold protein gephyrin in early and late stages of an Alzheimer's disease model. J Am Pathol: 2279-91

 

Kundu, A., Milosch, N., Antonietti, P., Baumkötter, F., Zymny, A., Müller, U.C., Kins, S., Hajieva, P., Behl, C., Kögel, D., (2015) Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP. Mol Neurobiol.:DOI 10.1007/s12035-015-9501-y

 

Hermey, G., Schmidt, N., Bluhm, B., Mensching, D., Ostermann, K., Rupp, C., Kuhl, D., Kins, S., (2015) SorCS1 variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCS1c modulates anterograde APP transport. J Neurochem. 135(1):60-75

 

Renziehausen, J., Hiebel, C., Nagel, H., Kundu, A., Kins, S., Kögel, D., Behl, C., Hajieva, P., (2014) The Cleavage Product of Amyloid-ß Protein Precursor sAβPPα Modulates BAG3-Dependent Aggresome Formation and Enhances Cellular Proteasomal Activity. J Alzheimers Dis. 1,44 (3): 879-96

 

Milosch, N., Tanriöver, G., Kundu, A., Rami, A., François, J.C., Baumkötter, F., Weyer, S.W., Samanta, A., Jäschke, A., Brod, F., Buchholz, C.J., Kins, S., Behl, C., Müller, U.C., Kögel, D., (2014) Holo-APP and G-protein-mediated signaling are required for sAPPa-induced activation of the akt survival pathway. Cell Death Dis. 28;5: e1391

 

Stahl, R.*, Schilling, S.*, Soba, P., Rupp, C., Hartmann, T., Wagner, K., Merdes, G., Eggert, S.*, Kins, S.*, (2014) Shedding of APP limits its synaptogenic and cell adhesion properties. Frontiers Cell Neurosci 8:00410

 

Klevanski, M., Saar, M., Baumkötter, F., Weyer, S.W., Kins, S., Müller, U.C., (2014) Differential role of APP and APLPs for neuromuscular synaptic morphology and function. Mol. Cell. Neurosci. 61C: 201-210

 

Baumkötter, F., Schmidt, N., Vargas, C., Schilling, S., Weber, R., Wagner, K., Fiedler, S., Klug, W., Radzimanowski, J., Nickolaus, S., Keller, S., Eggert, S., Wild, K., Kins, S., (2014) Amyloid Precursor Protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain. J. Neurosci. 34(33): 11159-11172

 

Rupp, C., Beyreuther, K., Maurer, K., Kins, S., (2014) A presenilin 1 mutation in the first case of Alzheimer's disease: Revisited. Alzheimers Dement 10(6): 869-72 

 

Nagahara, A.H., Mateling, M., Kovacs, I., Wang, L., Eggert, S., Rockenstein, E., Koo, E.H., Masliah, E., Tuszynski, M.H., (2013) Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. J. Neurosci. 25;33(39): 15596-602

 

Jung, H.J., Kim, Y.J., Eggert, S., Chung, K.C., Choi, K.S., Park, S.A., (2013) Age-dependent increases in tau phosphorylation in the brains of type 2 diabetic rats correlate with a reduced expression of p62. Exp Neurol. 248: 441-50

 

Thyrock, A., Ossendorf, E., Stehling, M., Kail, M., Kurtz, T., Pohlentz, G., Waschbüsch, D., Eggert, S., Formstecher, E., Müthing, J., Dreisewerd, K., Kins, S., Goud, B., Barnekow, A., (2013) A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6. PLoS One 30;8(5): e64149

 

Riemer, J., Kins, S., (2012) AxonalTransport and Mitochondrial Dysfunction in Alzheimer's Disease. Neurodegener Dis. 2013; 12(3):111-24

 

Isbert, S., Wagner, K., Eggert, S., Schweitzer, A., Multhaup, G., Weggen, S., Kins, S., Pietrzik, C., (2011) APP Dimer Formation is initiated in the Endoplasmic Reticulum and Differs between APP Isoforms. CMLS 2012 Apr;69(8):1353-75. Epub 2011 Nov 22. 1353-75.

 

Brunholz, S., Sisodia, S., Lorenzo, A., Deyts, C., Kins, S., Morfini, G. (2011) Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells . Exp Brain Res 2012 Apr;217(3-4):353-64. Epub 2011 Sep 30. 353-64.

 

Baumkötter, F., Wagner, K., Eggert, S., Wild, K., Kins, S. (2011) Structural aspects and physiological consequences of APP/APLP trans-dimerization. Exp Brain Res 2012 Apr;217(3-4):389-95. Epub 2011 Sep 28. 389-95.

 

Grimm, M., Rothhaar, T., Grösgen, S., Burg, V., Hundsdörfer, B., Haupenthal, V., Friess, P., Kins, S., Grimm, H., Hartmann, T. (2011) Trans fatty acids enhance amyloidogenic processing of Alzheimer Amyloid Precursor Protein (APP). JNB 1214-1223.

 

Szodorai, A., Kuan, Y.-H., Hunzelmann, S., Engel, U., Sakane, A., Sasaki, T., Takai, Y., Kirsch, J., Müller, U., Beyreuther, K., Brady, S., Morfini, G., Kins, S.(2009) APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. J. Neurosci. 29(46): 14534-44.

 

Kins, S. and Beyreuther, K. (2009) Alzheimer’s Disease. In: „Encyclopedia of Molecular Mechanisms of Disease“, Springer Verlag.

 

Deboer, S.R., You, Y., Szodorai, A., Kaminska, A., Pigino, G., Nwabuisi, E., Wang, B., Estrada-Hernandez, T., Kins, S., Brady, S.T., Morfini, G. (2008) Conventional Kinesin holoenzymes are composed of heavy and light chain homodimers. Biochem. 47: 4535-43.

 

Back, S., Haas, P., Tschaepe, J.-A., Gruebl, T., Kirsch, J., Mueller, U., Beyreuther, K., Kins, S.. In neurons APP can be transported independent of any sorting signal to the axonal and dendritic compartment. J. Neurosci. Res. 85 (12): 2580–90.

 

Rusu, P., Jansen, A., Soba, P., Kirsch, J., Loewer, A., Merdes, G., Kuan, Y.-H., Jung, A., Beyreuther, K., Kjaerulff, O., Kins, S. Axonopathy in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity, Eur. J. Neurosci. 2007 Feb; 25 (4): 1079-86.

 

Kuan, Y.-H., Gruebl, T., Soba, P., Eggert, S., Nesic, I., Kirsch, J., Beyreuther, K., Kins, S. The processing and anterograde transport of APP, APLP1 and APLP2 is affected by the carboxyl-terminal binding partner PAT1a J. Biol. Chem., 2006, 281(52): 40114-123.

 

Kins, S., Lauther, N., Szodorai, A., and Beyreuther, K. Subcellular trafficking of the APP gene family and its pathogenic role in Alzheimer's Disease. Neurodegener Dis. 2006; 3 (4-5): 218-26.

 

Kins, S., Beyreuther, K. Teasing out the tangles. Nat. Med., 2006; 12(7): 764-5.

 

Goetz, J., Ittner, L.M., and Kins, S. Do axonal defects in tau and APP transgenic animals model axonopathy in Alzheimer's disease?, J. Neurochem., 2006; 98(4): 993-1006.

 

Hoerster F, Schwab MA, Sauer SW, Pietz J, Hoffmann GF, Okun JG, Kolker S,Kins S. Phenylalanine reduces synaptic density in mixed cortical cultures from mice. Pediatr. Res., 2006; 59(4 Pt 1): 544-8.

 

Soba, P., Eggert, S., Wagner, K., Zentgraf, H., Siehl, K., Kreger, S., Lower, A., Langer, A., Merdes, G., Paro, R., Masters, C.L., Mueller, U., Kins, S., Beyreuther, K. Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J., 2005, 24 (20): 3624-36.

 

von Rotz, R.C., Kins, S., Hipfel, R., von der Kammer, H., Nitsch, R.M. The cytosolic ring finger protein dactylidin is selectively upregulated in brains of patients with Alzheimer's disease. Eur. J. Neurosci. 2005, 21 (5): 1289-98.

 

Lazarov, O., Morfini, G.A., Szodorai, A., Kins, S., Lee, V., Trojanowski, J., Price, D., Brady, S.T., Sisodia, S.S. Axonal Transport, APP, Kinesin and the Processing Apparatus: Revisited. J. Neurosci. 2005, 25 (9): 2386-95.

 

Kins, S., Kurosinski, P., Nitsch, R.M. and Goetz, J. Hyperphosphorylation and somatodendritic localization of tau in PP2A dominant negative mutant mice is associated with activation of ERK and JNK signaling. Am. J. Pathol., 2003, 163 (3): 833-843.

 

Schmidt, K., Kins, S., Schild, A., Nitsch, R.M., Hemmings, B. and Goetz, J. Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A. Eur. J. Neurosci., 2002, 16 (11): 2039-48

 

Fuhrmann, J.C., Kins, S., Kirsch, J., Kneussel, M., Betz, H. Gephyrin interacts with DLC-1/PIN and DLC-2, components of the cytoplasmic dynein complex. J. Neurosci., 2002, 22 (13): 5393-402.

 

Mueller, U. und Kins, S. APP on the move. Trends Mol Med. 2002, 8 (4):152-5.

 

Steinhoff, T., Moritz, E., Wollmer, M. A., Mohajeri, M. H., Kins, S. and Nitsch, R. M. Increased cystatin C in astrocytes of transgenic mice expressing the K670N-M671L mutation of the amyloid precursor protein and deposition in brain amyloid plaques.  Neurobiol. Dis. 2001, 8 (4): 647-54.

 

Kins, S., Crameri, A., Evans, D. R., Hemmings, B. A., Nitsch, R. M., and Goetz, J. Reduced PP2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. J. Biol. Chem. 2001, 276 (41): 38193-200.

 

Grosskreutz, Y., Hermann, A., Kins, S., Fuhrmann, J. C., Betz, H., and Kneussel, M. Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin. Biol. Chem. 2000, 382 (10): 1455-1462.

 

Ramming, M., Kins, S., Werner, N., Hermann, A., Betz, H., and Kirsch, J. Diversity and phylogeny of gephyrin: tissue-specific splice variants, gene structure, and sequence similarities to molybdenum cofactor-synthesizing and cytoskeleton-associated proteins. Proc Natl Acad Sci U S A 2000, 97 (18): 10266-10271.

 

Kins, S., Betz, H., and Kirsch, J. Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin. Nat Neurosci 2000, 3 (1): 22-29.

 

Kins, S., Kuhse, J., Laube, B., Betz, H. and Kirsch, J. Incorporation of a gephyrin-binding motif targets NMDA receptors to gephyrin-rich domains in HEK 293 cells. Eur. J. Neurosci. 1999, 11 )2):740-4.

 

*authors contributed equally