Fachgebiet Humanbiologie

Research Associate

Contact:

Human Biology
TU Kaiserslautern
Erwin-Schrödinger-Straße/Geb. 13, Room 115
67663 Kaiserslautern

Tel.: +49 (0)631-205-2405
Fax: +49 (0)631-205-3517

Email: s.eggert[at]biologie.uni-kl.de

Curriculum Vitae Dr. Simone Eggert

since January 2011: Senior Scientist in the lab of Prof. Dr. Stefan Kins at the TU Kaiserslautern

January 2005 - December 2010: post-doctoral fellow in the lab of Prof. Dr. Edward Koo, University of California, San Diego (UCSD), Department of Neurosciences, USA

August 2004 - December 2004: post-doctoral fellow in the lab of Prof. Dr. Dr. h.c. Konrad Beyreuther at the University of Heidelberg, ZMBH

April 2003 - June 2003: University of Melbourne, Australia in the lab of Prof. Colin L. Masters under the supervision of Dr. Genevieve Evin as a part of the PhD thesis

March 2000 - July 2004: PhD thesis in the lab of Prof. Dr. Dr. h.c. Konrad Beyreuther at the University of Heidelberg, ZMBH

April 1999 - January 2000: Diploma thesis in the lab of Prof. Dr. Dr. h.c. Konrad Beyreuther at the University of Heidelberg, ZMBH, Germany


Scholarships / Awards

July 2008 - July 2009: Post-doctoral fellowship, Ellison Medical foundation / American Federation for Aging Research (AFAR), USA

February 2006 - February 2008 - Post-doctoral fellowship, DFG (Deutsche Forschungsgemeinschaft) (for stay at UCSD, San Diego in Prof. Dr. Koo's lab)

January 2003: Boehringer-Ingelheim travel fellowship for working 3 months at the University of Melbourne, Australia, in the lab of Prof. Colin L. Masters as part of the PhD thesis

June 2000: Award for diploma thesis by the GFM "Gesellschaft zur Förderung der molekularbiologischen Forschung in Heidelberg"


Major Research Interest


Selected Publications

1. Eggert, S., Kins, S., Thomas, C., Hermey, G, Trafficking in Alzheimer’s disease: Modulation of APP transport and processing by the transmembrane proteins LRP1, SorLA, SorcS1c, Sortilin and Calsyntenin, Mol Neurobiol. 2018 Jul;55(7):5809-5829. doi: 10.1007/s12035-017-0806-x. Epub 2017 Oct 27. Review.

2. Eggert, S.,* Gonzalez, AC.,* Thomas, C., Schwarz, SM., Tischer, C., Schilling, S., Strecker, P., Schmidt, V., Willnow, TE., Hermey, G., Pietrzik, CU., Koo, EH, Kins, S. Dimerization leads to changes in APP (Amyloid Precursor Protein) trafficking mediated by LRP1 and SorLA, Journal of Cellular and Molecular Life Sciences, 2018 Jan;75(2):301-322. doi: 10.1007/s00018-017-2625-7. Epub 2017 Aug 10. PMID:28799085

3. Schilling, S.,* Mehr, A.,*, Ludewig, S., Stephan, J., Zimmermann, M., August, A., Strecker, P., Korte, M., Koo, EH., Müller, U.,*, Kins, S.,*, Eggert, S.* Synaptic Cell adhesion molecule APLP1 is required for maintenance of dendritic spines and basal synaptic transmission J Neurosci  2017 May 24;37(21):5345-5365. doi: 10.1523/JNEUROSCI.1875-16.2017. Epub 2017 Apr 27, (citations: 12), IF 2015: 5,9

4. Stahl, R., Schilling, S., Soba, P., Rupp, C., Hartmann, T., Wagner, K., Merdes, G., Eggert, S.* and Kins, S.* Shedding of the Amyloid precursor protein limits its synaptogenic and cell adhesion activity Front Cell Neurosci 2014 Dec 03; 3;8:410doi: 10.3389/fncel.2014.00410. eCollection 2014

5. Tyan, SH., Shih, AY., Walsh, JJ., Maruyama, H., Sarsoza, F., Ku, L., Eggert, S., Hof, PR., Koo, EH., Dickstein, DL. Amyloid precursor protein (APP) regulates synaptic structure and function. Mol and Cell Neurosci 2012 51(1-2):43-52

6. Midthune, B., Tyan, SH., Walsh, JJ., Sarsoza, F., Eggert, S., Hof, PR., Dickstein, DL., Koo, EH. Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function. Mol and Cell Neurosci 2012 49(4):448-55

7. Eggert, S., Midthune, B., Cottrell, B., Koo, E.H. Induced dimerization of APP leads to decreased Amyloid-β protein (Aβ) production. J Biol Chem 2009 284(42), 28943-52

8. Soba, P., Eggert, S., Wagner, K., Zentgraf, H., Siehl, K., Kreger, S., Loewer, A., Langer, A., Merdes, G., Paro, R., Masters, CL., Mueller, U., Kins, S., and Beyreuther, K. Homo- and Heterodimerization of APP family members promotes intercellular adhesion. The EMBO Journal 2005 24(20), 3624-3634         

9. Eggert, S., Paliga, K., Soba, P., Evin, G. Masters, C.L., Weidemann, A., and Beyreuther, K. The proteolytic processing of the Amyloid Precursor Protein gene family members APLP-1 and APLP-2 involves α-, β-, γ- and ε-like cleavages. Modulation of APLP-1 processing by glycosylation. J Biol Chem 2004 279(18), 18146-56

10. Weidemann, A., Eggert, S., Reinhard, F.B.M., Vogel, M., Paliga, K., Baier,G., Masters, C.L., Beyreuther,K., and Evin, G. A novel ε-Cleavage within the Transmembrane Domain of the Alzheimer Amyloid Protein Demonstrates Homology with Notch Processing. Biochemistry 2002 41(8), 2825-2835

complete list of publications

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