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Peer-Reviewed Publications

VIPP1 rods engulf membranes containing phosphatidylinositol phosphates.
Theis J, Gupta T, Klingler J, Wan W, Albert S, Keller S, Engel B, Schroda M.
Sci. Rep. 2019, accepted.

Structural determinants of the interaction between influenza A virus matrix protein M1 and lipid membranes.
Hoefer CT, Di Lella S, Dahmani I, Jungnick N, Bordag N, Bobone S, Huang Q, Keller S, Herrmann A, Chiantia S.
Biochim. Biophys. Acta 2019, 1861, 1123–1134.

Influence of Mg2+ and Ca2+ on nanodisc formation by diisobutylene/maleic acid (DIBMA) copolymer.
Danielczak B, Meister A, Keller S.
Chem. Phys. Lipids 2019, 221, 30–38.

Hydrogenated diglucose detergents for membrane-protein extraction and stabilization.
Guillet P, Mahler F, Garnier K, Nyame Mendendy Boussambe G, Igonet S, Vargas C, Ebel C, Soulié M, Keller S, Jawhari A, Durand G.
Langmuir 2019, 35, 4287–4295.

Carbon's three-center-four-electron tetrel bond, treated experimentally.
Karim A, Schulz N, Andersson H, Nekoueishahraki B, Carlsson AC, Sarabi D, Valkonen A, Rissanen K, Gräfenstein J, Keller S, Erdélyi M.
J. Am. Chem. Soc. 2018, 140, 17571–17579.

Collisional lipid exchange among DIBMA-encapsulated nanodiscs (DIBMALPs).
Danielczak B, Keller S.  
Eur. Polym. J. 201810, 206–213.

Conformational dynamics govern the free-energy landscape of a membrane-interacting protein.
Frotscher E, Krainer G, Hartmann A, Schlierf M, Keller S.
ACS Omega 2018, 3, 12026–12032.
ACS Omega

A minimal helical-hairpin motif provides molecular-level insights into misfolding and pharmacological rescue of CFTR.
Krainer G, Treff A, Hartmann A, Stone TA, Schenkel M, Keller S, Deber CM, Schlierf M.
Commun. Biol. 2018, 154, 1–7.
Communications Biology

Rationalizing steroid interactions with lipid membranes: conformations, partitioning, and kinetics.
Atkovska K, Klingler J, Oberwinkler J, Keller S, Hub JS.
ACS Cent. Sci. 20184, 1155–1165.

Aggregation behavior of pHLIP in aqueous solution at low concentrations: a fluorescence study.
Rao BD, Chakraborty H, Keller S, Chattopadhyay A.  
J. Fluoresc. 2018, 28, 967–973.

Lipid membranes and reactions at lipid interfaces: theory, experiments, and applications.
Bondar AN, Keller S.
J. Membr. Biol. 2018, 251, 295–298.

Fluorinated diglucose detergents for membrane-protein extraction.
Boussambe GNM, Guillet P, Mahler F, Marconnet A, Vargas C, Cornut D, Soulié M, Ebel C, Le Roy A, Jawhari A, Bonneté F, Keller S, Durand G.
Methods 2018, 147, 84–94.

Extracavity effect in cyclodextrin/surfactant complexation.
Vargas C, Schönbeck C, Heimann I, Keller S.
Langmuir 201834, 5781–5787.

Dissecting nanosecond dynamics in membrane proteins with dipolar relaxation upon tryptophan photoexcitation. 
Frotscher E, Krainer G, Schlierf M, Keller S.
J. Phys. Chem. Lett. 2018, 9, 2241–2245.

Role of Coulombic repulsion in collisional lipid transfer among SMA(2:1)-bounded nanodiscs. 
Grethen A, Glueck D, Keller S.
J. Membr. Biol. 2018, 251, 443–451.

Formation of lipid-bilayer nanodiscs by diisobutylene/maleic acid (DIBMA) copolymer. 
Oluwole AO, Klingler J, Danielczak B, Babalola JO, Vargas C, Pabst G, Keller S.
Langmuir 2017, 33, 14378–14388.

Ultrafast protein folding in membrane-mimetic environments.
Krainer G, Hartmann A, Anandamurugan A, Gracia P, Keller S, Schlierf M.
J. Mol.
Biol. 2018, 430, 554–564.

Thermodynamics of nanodisc formation mediated by styrene/maleic acid (2:1) copolymer.
Grethen A, Oluwole AO, Danielczak B, Vargas C, Keller S.
Sci. Rep. 2017, 7, 11517.

Structural and molecular comparison of bacterial and eukaryotic trigger factors.
Ries F, Carius Y, Rohr M, Gries K, Keller S, Lancaster CRD, Willmund F.
Sci. Rep. 2017, 7, 10680.

Slow interconversion in a heterogeneous unfolded-state ensemble of outer-membrane phospholipase A.
Krainer G, Gracia P, Frotscher E, Hartmann A, Gröger P, Keller S, Schlierf M.
Biophys. J. 2017, 113, 1280–1289.

Fast collisional lipid transfer among polymer-bounded nanodiscs.
Cuevas Arenas R, Danielczak B, Martel A, Porcar L, Breyton C, Ebel C, Keller S.
Sci. Rep. 2017, 7, 45875.

Real-time visualization of phospholipid degradation by outer membrane phospholipase A using high-speed atomic force microscopy.
Rangl M, Rima L, Klement J, Miyagi A, Keller S, Scheuring S.
J. Mol. Biol. 2017, 429, 977–986.

Model-free analysis of critical micellar concentrations for detecting demixing in surfactant mixtures.
Frotscher E, Höring J, Durand G, Vargas C, Keller S.
Anal. Chem. 2017, 89, 3245–3249.

Solubilization of membrane proteins into functional lipid-bilayer nanodiscs by diisobutylene/maleic acid copolymer.
Oluwole AO, Danielczak B, Meister A, Babalola JO, Vargas C, Keller S.  
Angew. Chem. Int. Ed. 201756, 1919–1924.

Oxoanion binding to a cyclic pseudopeptide containing 1,4-disubstituted 1,2,3-triazole moieties.
Mungalpara D, Kelm H, Valkonen A, Keller S, Kubik S.
Org. Biomol. Chem. 2016, 15, 102–113.

Influence of lipid bilayer properties on nanodisc formation mediated by styrene/maleic acid copolymers.
Cuevas Arenas R, Klingler J, Vargas C, Keller S.
Nanoscale 20168, 15016–15026.

Journal of Membrane Biology: Biophysics.
Keller S, Bondar AN, Broecker J, Ladokhin AS, Sinner EK.
J. Membr. Biol. 2016, 249, 5.

Sparingly fluorinated maltoside-based surfactants for membrane-protein stabilization.
Polidori A, Raynal S, Barret LA, Dahani M, Barrot-Ivolot C, Jungas C, Frotscher E, Keller S, Ebel C, Breyton C, Bonneté F. 
New J. Chem. 2016, 40, 5364–5378.

Integration and global analysis of isothermal titration calorimetry data for studying macromolecular interactions.
Brautigam CA, Zhao H, Vargas C, Keller S, Schuck P.
Nat. Protoc. 201611, 882–894.

Reversible unfolding of rhomboid intramembrane proteases.
Panigrahi R, Arutyunova E, Panwar P, Gimpl K, Keller S, Lemieux MJ.
Biophys. J. 2016110, 1379–1390.

Characterising protein/detergent complexes by triple-detection size-exclusion chromatography.
Gimpl K, Klement J, Keller S.
Biol. Proced. Online 201618, 4.

Calorimetric quantification of cyclodextrin-mediated detergent extraction for membrane-protein reconstitution.
Textor M, Keller S.
Methods Enzymol. 2016, 567, 129–156.

Nanoparticle self-assembly in mixtures of phospholipids with styrene/maleic acid copolymers or fluorinated surfactants.
Vargas C, Cuevas Arenas R, Frotscher E, Keller S.
Nanoscale 2015, 7, 20685–20696.

Quantification of millisecond protein-folding dynamics in membrane-mimetic environments by single-molecule FRET spectroscopy.
Hartmann A, Krainer G, Keller S, Schlierf M.
Anal. Chem. 2015, 87, 11224–11232.

Multiple multidentate halogen bonding in solution, in the solid state, and in the (calculated) gas phase.
Jungbauer SH, Schindler S, Herdtweck E, Keller S, Huber SM.
Chemistry 2015, 21, 13625–13636.

Structural thermodynamics of myr-Src(2–19) binding to phospholipid membranes.
Scheidt HA, Klingler J, Huster D, Keller S.
Biophys. J. 2015, 109, 586–594.

Automated analysis of calorimetric demicellisation titrations.
Textor M, Keller S.
Anal. Biochem. 2015, 485, 119–121.

Modulating bilayer mechanical properties to promote the coupled folding and insertion of an integral membrane protein.
Herrmann M, Danielczak B, Textor M, Klement J, Keller S.
Eur. Biophys. J. 2015, 44, 503–512.

Chaires JB, Hansen LD, Keller S, Brautigam CA, Zhao H, Schuck P.
Methods 2015, 76, 1–2.

A fluorinated detergent for membrane-protein applications.
Frotscher E, Danielczak B, Vargas C, Meister A, Durand G, Keller S.
Angew. Chem. Int. Ed. 2015, 54, 5069–5073.

Preparation of ready-to-use small unilamellar phospholipid vesicles by ultrasonication with a beaker resonator.
Klingler J, Vargas C, Fiedler S, Keller S.
Anal. Biochem. 2015, 477, 10–12.

Micellar and biochemical properties of a propyl-ended fluorinated surfactant designed for membrane-protein study.
Abla M, Unger S, Keller S, Bonneté F, Ebel C, Pucci B, Breyton C, Durand G.
J. Colloid Interface Sci. 2015, 445, 127–136.

Calorimetric quantification of linked equilibria in cyclodextrin/lipid/detergent mixtures for membrane-protein reconstitution.
Textor M, Vargas C, Keller S.
Methods 2015, 76, 183–193.

Single-experiment displacement assay for quantifying high-affinity binding by isothermal titration calorimetry.
Krainer G, Keller S.
Methods 2015, 76, 116–123.

Sequence-specific dimerization of a transmembrane helix in amphipol A8-35.
Stangl M, Unger S, Keller S, Schneider D.
PLoS One 20149, e110970.

Mistic's membrane association and its assistance in overexpression of a human GPCR are independent processes.
Marino J, Bordag N, Keller S, Zerbe O.
Protein Sci. 201524, 38–48.

Self-assembly thermodynamics of pH-responsive amino acid-based polymers with a non-ionic surfactant.
Bogomolova AY, Keller S, Klingler J, Sedlak M, Rak D, Sturcova A, Hruby M, Stepanek P, Filippov SK.
Langmuir 2014, 30, 11307–11318.

Polar interactions trump hydrophobicity in stabilizing the self-inserting membrane protein Mistic.
Broecker J, Fiedler S, Gimpl K, Keller S.
J. Am. Chem. Soc. 2014, 136, 13761–13768.

Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain.
Baumkötter F, Schmidt N, Vargas C, Schilling S, Weber R, Wagner K, Fiedler S, Klug W, Radzimanowski J, Nickolaus S, Keller S, Eggert S, Wild K, Kins S.
J. Neurosci. 2014, 34, 11159–11172.

Analysis of selected and designed chimeric D- and L-α-helix assemblies.
Kükenshöner T, Hagemann UB, Wohlwend D, Räuber C, Baumann T, Keller S, Einsle O, Müller KM, Arndt KM.
Biomacromolecules 2014, 15, 3296–3305.

Small-molecule inhibitors of AF6 PDZ-mediated protein–protein interactions.
Vargas C, Radziwill G, Krause G, Diehl A, Keller S, Kamdem N, Czekelius C, Kreuchwig A, Schmieder P, Doyle D, Moelling K, Hagen V, Schade M, Oschkinat H.
ChemMedChem 2014, 9, 1458–1462.

Structure–activity relationships of the antimicrobial peptide gramicidin S and its analogues: aqueous solubility, self association, conformation, antimicrobial activity and interactions with model lipid membranes.
Abraham T, Prenner EJ, Lewis RN, Mant CT, Keller S, Hodges RS, McElhaney RN.
Biochim. Biophys. Acta 2014, 1838, 1420–1429.

New and Notable: How membrane partitioning modulates receptor activation: parallel versus serial effects of hydrophobic ligands.
Heerklotz H, Keller S.
Biophys. J. 2013105, 2607–2610.

Real-time monitoring of membrane-protein reconstitution by isothermal titration calorimetry.
Jahnke N, Krylova O, Hoomann T, Vargas C, Fiedler S, Pohl P, Keller S.
Anal. Chem. 2014, 86, 920–927.

The mechanism of denaturation and the unfolded state of the α-helical membrane-associated protein Mistic.
Jacso T, Bardiaux B, Broecker J, Fiedler S, Baerwinkel T, Mainz A, Fink U, Vargas C, Oschkinat H, Keller S, Reif B.
J. Am. Chem. Soc. 2013, 135, 18884–18891.

Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels.
Vocke K, Dauner K, Hahn A, Ulbrich A, Broecker J, Keller S, Frings S, Möhrlen F.
J. Gen. Physiol. 2013, 142, 381–404.

Membrane partitioning and translocation studied by isothermal titration calorimetry.
Vargas C, Klingler J, Keller S.
Methods Mol. Biol. 2013, 1033, 253–271.

Filter gate closure inhibits ion but not water transport through potassium channels.
Hoomann T, Jahnke N, Horner A, Keller S, Pohl P.
Proc. Natl. Acad. Sci. USA 2013, 110, 10842–10847.

Impact of urea on detergent micelle properties.
Broecker J, Keller S.
Langmuir 2013, 29, 8502–8510.

Automated circular dichroism spectroscopy for medium-throughput analysis of protein conformation.
Fiedler S, Cole L, Keller S.
Anal. Chem. 2013, 85, 1868–1872.

Quantifying high-affinity binding of hydrophobic ligands by isothermal titration calorimetry.
Krainer G, Broecker J, Vargas C, Fanghänel J, Keller S.
Anal. Chem. 2012, 84, 10715–10722.

Coumarin-based octopamine phototriggers and their effects on an insect octopamine receptor.
Schaal J, Dekowski B, Wiesner B, Eichhorst J, Marter K, Vargas C, Keller S, Eremina N, Barth A, Baumann A, Eisenhardt D, Hagen V.
ChemBioChem 2012, 13, 1458–1464.

High-precision isothermal titration calorimetry with automated peak-shape analysis.
Keller S, Vargas C, Zhao H, Piszczek G, Brautigam CA, Schuck P.
Anal. Chem. 2012, 84, 5066–5073.

Ring A of nukacin ISK-1: a lipid II-binding motif for type-A(II) lantibiotic.
Islam MR, Nishie M, Nagao J, Keller S, Nakayama J, Kohda D, Sahl HG, Sonomoto K.
J. Am. Chem. Soc. 2012, 134, 3687–3690.

Mutations of ventricular essential myosin light chain disturb myosin binding and sarcomeric sorting.
Lossie J, Ushakov DS, Ferenczi MA, Werner S, Keller S, Haase H, Morano I.
Cardiovasc. Res. 2012, 93, 390–396.

Characterization of membrane proteins in isolated native cellular membranes by dynamic nuclear polarization solid-state NMR spectroscopy without purification and reconstitution.
Jacso T, Franks WT, Rose H, Fink U, Broecker J, Keller S, Oschkinat H, Reif B.
Angew. Chem. Int. Ed. 2012, 51, 432–435.

Mia40-dependent oxidation of cysteines in domain I of Ccs1 controls its distribution between mitochondria and the cytosol.
Klöppel C, Suzuki Y, Kojer K, Petrungaro C, Longen S, Fiedler S, Keller S, Riemer J.
Mol. Biol. Cell 201122, 3749–3757.

Revisiting the optimal c value for isothermal titration calorimetry.
Broecker J, Vargas C, Keller S.
Anal. Biochem. 2011, 418, 307–309.

Distinct binding properties distinguish LQ-type calmodulin-binding domains in cyclic nucleotide-gated channels. 
Ungerer N, Mücke N, Broecker J, Keller S, Frings S, Möhrlen F. 
Biochemistry 2011, 50, 3221–3228.

Human essential myosin light chain isoforms revealed distinct myosin binding, sarcomeric sorting, and inotropic activity.
Petzhold D, Lossie J, Keller S, Werner S, Haase H, Morano I.
Cardiovasc. Res. 2011, 90, 513–520.

A myomesin mutation associated with hypertrophic cardiomyopathy deteriorates dimerisation properties.
Segert R, Perrot A, Keller S, Behlke J, Michalewska-Włudarczyk A, Wycisk A, Tendera M, Morano I, Ozcelik C.
Biochem. Biophys. Res. Commun. 2011, 405, 473479

Interaction of W-substituted analogs of cyclo-RRRWFW with bacterial lipopolysaccharides: the role of the aromatic cluster in antimicrobial activity.
Bagheri M, Keller S, Dathe M.
Antimicrob. Agents Chemother. 2011, 55, 788–792.

Short cationic antimicrobial peptides interact with ATP.
Hilpert K, McLeod B, Yu J, Elliott MR, Rautenbach M, Ruden S, Bürck J, Muhle-Goll C, Ulrich AS, Keller S, Hancock RE.
Antimicrob. Agents Chemother. 2010, 54, 4480–4483.

Auto-inhibitory effects of an IQ motif on protein structure and function.
Petzhold D, Lossie J, Behlke J, Keller S, Haase H, Morano I. 
Biochem. Biophys. Res. Commun. 2010, 396, 939–943.

Membrane solubilisation and reconstitution by octylglucoside: comparison of synthetic lipid and natural lipid extract by isothermal titration calorimetry.
Krylova OO, Jahnke N, Keller S.
Biophys. Chem. 2010, 150, 105–111.

Nonlinear least-squares data fitting in Excel spreadsheets.
Kemmer G, Keller S.
Nat. Protoc. 2010, 5, 267–281.

Crystal structures of the solute receptor GacH of Streptomyces glaucescens in complex with acarbose and an acarbose homolog: comparison with the acarbose-loaded maltose-binding protein of Salmonella typhimurium.
Vahedi-Faridi A, Licht A, Bulut H, Scheffel F, Keller S, Wehmeier UF, Saenger W, Schneider E. 
J. Mol. Biol. 2010, 397, 709–723. 

Protein folding in membranes.
Fiedler S, Broecker J, Keller S.
Cell. Mol. Life Sci. 2010, 67, 1779–1798.

Membrane translocation assayed by fluorescence spectroscopy.
Broecker J, Keller S. 
Methods Mol. Biol. 2010, 606, 271–289.

Molecular basis for association of PIPKIγ-p90 with clathrin adaptor AP-2.
Kahlfeldt N, Vahedi-Faridi A, Koo SJ, Schäfer JG, Krainer G, Keller S, Saenger W, Krauss M, Haucke V.
J. Biol. Chem. 2010, 285, 2734–2749.

α-helical transmembrane peptides: a "divide and conquer" approach to membrane proteins.
Bordag N, Keller S. 
Chem. Phys. Lipids 2010, 163, 1–26.

Selective identification of cooperatively binding fragments in a high-throughput ligation assay enables development of a picomolar caspase-3 inhibitor.
Schmidt MF, El-Dahshan A, Keller S, Rademann J.
Angew. Chem. Int. Ed. 2009, 48, 6346–6349.

Proline-rich sequence recognition II: proteomic analysis of Tsg101-UEV interactions.
Schlundt A, Sticht J, Piotukh K, Kosslik D, Jahnke N, Keller S, Schuemann M, Krause E, Freund C. 
Mol. Cell. Proteomics 2009, 8, 2474–2486.

Monitoring detergent-mediated solubilization and reconstitution of lipid membranes by isothermal titration calorimetry.
Heerklotz H, Tsamaloukas AD, Keller S.
Nat. Protoc. 2009, 4, 686–697.

Periplasmic loop P2 of the MalE subunit of the maltose ATP binding cassette transporter is sufficient to bind the maltose binding protein MalE.
Jacso T, Grote M, Daus ML, Schmieder P, Keller S, Schneider E, Reif B.
Biochemistry 2009, 48, 2216–2225.

Uptake and release protocol for assessing membrane binding and permeation by way of isothermal titration calorimetry.
Tsamaloukas A, Keller S, Heerklotz H.
Nat. Protoc. 2007, 2, 695–704.

A simple fluorescence-spectroscopic membrane translocation assay.
Keller S, Böthe M, Bienert M, Dathe M, Blume A.
ChemBioChem 2007, 8, 546–552.

A network of coiled-coil associations derived from synthetic GCN4 leucine zipper arrays.
Portwich M, Keller S, Strauss HM, Mahrenholz CC, Kramer A, Kretzschmar I, Volkmer R.
Angew. Chem. Int. Ed. 2007, 46, 1654–1657.

Caged capsaicins: new tools for the examination of TRPV1 channels in somatosensory neurons.
Gilbert D, Funk K, Lechler R, Keller S, Möhrlen F, Frings S, Hagen V.
ChemBioChem 2007, 8, 89–97.

Dipalmitoylation of a cellular uptake-mediating apolipoprotein E-derived peptide as a promising modification for stable anchorage in liposomal drug carriers.
Sauer I, Nikolenko H, Keller S, Abu Ajaj K, Bienert M, Dathe M.
Biochim. Biophys. Acta 2006, 1758, 552–561.

Thermodynamics of lipid membrane solubilization by sodium dodecyl sulfate.
Keller S, Heerklotz H, Jahnke N, Blume A.
Biophys. J. 2006, 90, 4509–4521.

A caged doxycycline analogue for photoactivated gene expression.
Cambridge SB, Geissler D, Keller S, Cürten B.
Angew. Chem. Int. Ed. 2006, 45, 2229–2231.

Monitoring lipid membrane translocation of sodium dodecyl sulfate by isothermal titration calorimetry.
Keller S, Heerklotz H, Blume A.
J. Am. Chem. Soc. 2006, 128, 1279–1286.

Coumarinylmethyl esters for ultrafast release of high concentrations of cyclic nucleotides upon one- and two-photon photolysis.
Hagen V, Dekowski B, Nache V, Schmidt R, Geissler D, Lorenz D, Eichhorst J, Keller S, Kaneko H, Benndorf K, Wiesner B.
Angew. Chem. Int. Ed. 2005, 44, 7887–7891.

A quantitative model describing the selective solubilization of membrane domains.
Keller S, Tsamaloukas A, Heerklotz H. 
J. Am. Chem. Soc. 2005, 127, 11469–11476. 

A critical reassessment of penetratin translocation across lipid membranes.
Bárány-Wallje E, Keller S, Serowy S, Geibel S, Pohl P, Bienert M, Dathe M.
Biophys. J. 2005, 89, 2513–2521.

Membrane-mimetic nanocarriers formed by a dipalmitoylated cell-penetrating peptide.
Keller S, Sauer I, Strauss H, Gast K, Dathe M, Bienert M.
Angew. Chem. Int. Ed. 2005, 44, 5252–5255.

(Coumarin-4-yl)methyl esters as highly efficient, ultrafast phototriggers for protons and their application to acidifying membrane surfaces.
Geissler D, Antonenko YN, Schmidt R, Keller S, Krylova OO, Wiesner B, Bendig J, Pohl P, Hagen V.
Angew. Chem. Int. Ed. 2005, 44, 1195–1198.

Book Chapters

Peptide–membrane interactions studied by isothermal titration calorimetry.
Klingler J, Keller S.
In Biocalorimetry: Foundations and Contemporary Approaches
Bastos M, Ed.; CRC Press: London, 2015, im Druck.

Pharmacological interference with protein–protein interactions mediated by coiled-coil motifs.
Strauss HM, Keller S.
In Handbook of Experimental Pharmacology 186: Protein–Protein Interactions as New Drug Targets
Klussmann E, Scott J, Eds.; Springer-Verlag: Berlin, 2008, 461–481.

Cellular uptake of liposomal and micellar carriers mediated by apoE-derived peptides.
Dathe M, Keller S, Sauer I, Bienert M.
In Handbook of Cell-Penetrating Peptides 2nd ed. Langel Ü, Ed.; CRC Press: Boca Raton, 2006, 483–503.


Peptide and protein affinity tag.
Keller S, Bordag N.
EP 10 075 359.9, US 61/376,083; deposited 23rd August 2010.