Fachgebiet Molekulare Biotechnologie & Systembiologie


Bertgen L, Muhlhaus T, Herrmann JM (2020) Clingy genes: Why were genes for ribosomal proteins retained in many mitochondrial genomes? Biochim Biophys Acta Bioenerg 1861: 148275

Garcia-Molina A, Kleine T, Schneider K, Muhlhaus T, Lehmann M, Leister D (2020) Translational Components Contribute to Acclimation Responses to High Light, Heat, and Cold in Arabidopsis. iScience 23: 101331

Gupta TK, Klumpe S, Gries K, Heinz S, Wietrzynski W, Ohnishi N, Niemeyer J, Schaffer M, Rast A, Strauss M, Plitzko JM, Baumeister W, Rudack T, Sakamoto W, Nickelsen J, Schuller JM, Schroda M, Engel BD (2020) Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity. bioRxiv: 2020.2008.2011.243204

Hammel A, Sommer F, Zimmer D, Stitt M, Muhlhaus T, Schroda M (2020) Overexpression of Sedoheptulose-1,7-Bisphosphatase Enhances Photosynthesis in Chlamydomonas reinhardtii and Has No Effect on the Abundance of Other Calvin-Benson Cycle Enzymes. Front Plant Sci 11: 868

Leisen T, Bietz F, Werner J, Wegner A, Schaffrath U, Scheuring D, Willmund F, Mosbach A, Scalliet G, Hahn M (2020) CRISPR/Cas with ribonucleoprotein complexes and transiently selected telomere vectors allows highly efficient marker-free and multiple genome editing in Botrytis cinerea. PLoS Pathog 16: e1008326

Martins Rodrigues C, Mudsam C, Keller I, Zierer W, Czarnecki O, Corral JM, Reinhardt F, Nieberl P, Fiedler-Wieschers K, Sommer FK, Schroda M, Muhlhaus T, Harms K, Flugge UI, Sonnewald U, Koch W, Ludewig F, Neuhaus HE, Pommerrenig B (2020) Vernalization Alters Sink and Source Identities and Reverses Phloem Translocation from Taproots to Shoots in Sugar Beet (Beta vulgaris). Plant Cell

Ries F, Herkt C, Willmund F (2020) Co-Translational Protein Folding and Sorting in Chloroplasts. Plants (Basel) 9

Saladi S, Boos F, Poglitsch M, Meyer H, Sommer F, Muhlhaus T, Schroda M, Schuldiner M, Madeo F, Herrmann JM (2020) The NADH Dehydrogenase Nde1 Executes Cell Death after Integrating Signals from Metabolism and Proteostasis on the Mitochondrial Surface. Mol Cell 77: 189-202 e186

Schroda M (2020) Phosphoinositides regulate chloroplast processes. Proc Natl Acad Sci U S A 117: 9154-9156

Theis J, Niemeyer J, Schmollinger S, Ries F, Rutgers M, Gupta TK, Sommer F, Muranaka LS, Venn B, Schulz-Raffelt M, Willmund F, Engel BD, Schroda M (2020) VIPP2 interacts with VIPP1 and HSP22E/F at chloroplast membranes and modulates a retrograde signal for HSP22E/F gene expression. Plant Cell Environ 43: 1212-1229

Tiwari B, Habermann K, Arif MA, Weil HL, Garcia-Molina A, Kleine T, Muhlhaus T, Frank W (2020) Identification of small RNAs during cold acclimation in Arabidopsis thaliana. BMC Plant Biol 20: 298

Trentmann O, Muhlhaus T, Zimmer D, Sommer F, Schroda M, Haferkamp I, Keller I, Pommerrenig B, Neuhaus HE (2020) Identification of Chloroplast Envelope Proteins with Critical Importance for Cold Acclimation. Plant Physiol 182: 1239-1255

Weber C, Vierengel N, Walter T, Behrendt T, Lucas T, Erkel G, Opatz T (2020) Total synthesis and biological evaluation of seven new anti-inflammatory oxacyclododecindione-type macrolactones. Org Biomol Chem 18: 5906-5917


Giesselmann G, Dietrich D, Jungmann L, Kohlstedt M, Jeon EJ, Yim SS, Sommer F, Zimmer D, Muhlhaus T, Schroda M, Jeong KJ, Becker J, Wittmann C (2019) Metabolic engineering of Corynebacterium glutamicum for high-level ectoine production - design, combinatorial assembly and implementation of a transcriptionally balanced heterologous ectoine pathway. Biotechnol J: e201800417

Moritz CP, Muhlhaus T, Tenzer S, Schulenborg T, Friauf E (2019) Poor transcript-protein correlation in the brain: negatively correlating gene products reveal neuronal polarity as a potential cause. J Neurochem 149: 582-604

Rohr M, Ries F, Herkt C, Gotsmann VL, Westrich LD, Gries K, Trosch R, Christmann J, Chaux-Jukic F, Jung M, Zimmer D, Muhlhaus T, Sommer F, Schroda M, Keller S, Mohlmann T, Willmund F (2019) The role of plastidic trigger factor serving protein biogenesis in green algae and land plants. Plant Physiol 179: 1093-1110

Schneider K, Mühlhaus T (2019) FSharpGephiStreamer: An idiomatic bridge between F# and network visualization. Journal of Open Source Software 4: 1445

Schroda M (2019) Good News for Nuclear Transgene Expression in Chlamydomonas. Cells 8

Theis J, Gupta TK, Klingler J, Wan W, Albert S, Keller S, Engel BD, Schroda M (2019) VIPP1 rods engulf membranes containing phosphatidylinositol phosphates. Sci Rep 9: 8725

Theis J, Lang J, Spaniol B, Ferte S, Niemeyer J, Sommer F, Zimmer D, Venn B, Mehr SF, Muhlhaus T, Wollman FA, Schroda M (2019) The Chlamydomonas deg1c mutant accumulates proteins involved in high light acclimation. Plant Physiol 18m: 1480-1497

Trosch R, Willmund F (2019) The conserved theme of ribosome hibernation: from bacteria to chloroplasts of plants. Biol Chem 400: 879-893

Zhao Q, Zhang X, Sommer F, Ta N, Wang N, Schroda M, Cong Y, Liu C (2019) Hetero-oligomeric CPN60 resembles highly symmetric group-I chaperonin structure revealed by Cryo-EM. Plant J 98: 798-812


Backes S, Hess S, Boos F, Woellhaf MW, Godel S, Jung M, Muhlhaus T, Herrmann JM (2018) Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences. J Cell Biol 217: 1369-1382

Crozet P, Navarro FJ, Willmund F, Mehrshahi P, Bakowski K, Lauersen KJ, Perez-Perez ME, Auroy P, Gorchs Rovira A, Sauret-Gueto S, Niemeyer J, Spaniol B, Theis J, Trosch R, Westrich LD, Vavitsas K, Baier T, Hubner W, de Carpentier F, Cassarini M, Danon A, Henri J, Marchand CH, de Mia M, Sarkissian K, Baulcombe DC, Peltier G, Crespo JL, Kruse O, Jensen PE, Schroda M, Smith AG, Lemaire SD (2018) Birth of a photosynthetic chassis: a MoClo toolkit enabling synthetic biology in the microalga Chlamydomonas reinhardtii. ACS Synth Biol 7: 2074-2086

Hammel A, Zimmer D, Sommer F, Muhlhaus T, Schroda M (2018) Absolute quantification of major photosynthetic protein complexes in Chlamydomonas reinhardtii using quantification concatamers (QconCATs). Front Plant Sci 9: 1265

Kuken A, Sommer F, Yaneva-Roder L, Mackinder LC, Hohne M, Geimer S, Jonikas MC, Schroda M, Stitt M, Nikoloski Z, Mettler-Altmann T (2018) Effects of microcompartmentation on flux distribution and metabolic pools in Chlamydomonas reinhardtii chloroplasts. Elife 7

Muller N, Leroch M, Schumacher J, Zimmer D, Konnel A, Klug K, Leisen T, Scheuring D, Sommer F, Muhlhaus T, Schroda M, Hahn M (2018) Investigations on VELVET regulatory mutants confirm the role of host tissue acidification and secretion of proteins in the pathogenesis of Botrytis cinerea. New Phytol 219: 1062-1074

Rudolph A-K, Walter T, Erkel G (2018) The fungal metabolite cyclonerodiol inhibits IL-4/IL-13 induced Stat6-signaling through blocking the association of Stat6 with p38, ERK1/2 and p300. International Immunopharmacology 65: 392-401

Trosch R, Barahimipour R, Gao Y, Badillo-Corona JA, Gotsmann VL, Zimmer D, Muhlhaus T, Zoschke R, Willmund F (2018) Commonalities and differences of chloroplast translation in a green alga and land plants. Nat Plants 4: 564-575

Zimmer D, Schneider K, Sommer F, Schroda M, Muhlhaus T (2018) Artificial intelligence understands peptide observability and assists with absolute protein quantification. Front Plant Sci 9: 1559


Auerbach H, Kalienkova V, Schroda M, Schünemann V (2017) Mössbauer spectroscopy of the chloroplast-targeted DnaJ-like proteins CDJ3 and CDJ4. Hyperfine Interactions 238: 86

Ries F, Carius Y, Rohr M, Gries K, Keller S, Lancaster CRD, Willmund F (2017) Structural and molecular comparison of bacterial and eukaryotic trigger factors. Sci Rep 7: 10680

Rohr M, Oleinikov K, Jung M, Sandjo LP, Opatz T, Erkel G (2017) Anti-inflammatory tetraquinane diterpenoids from a Crinipellis species. Bioorganic & Medicinal Chemistry 25: 514-522

Rutgers M, Muranaka LS, Muhlhaus T, Sommer F, Thoms S, Schurig J, Willmund F, Schulz-Raffelt M, Schroda M (2017) Substrates of the chloroplast small heat shock proteins 22E/F point to thermolability as a regulative switch for heat acclimation in Chlamydomonas reinhardtii. Plant Mol Biol 95: 579-591

Rutgers M, Muranaka LS, Schulz-Raffelt M, Thoms S, Schurig J, Willmund F, Schroda M (2017) Not changes in membrane fluidity but proteotoxic stress triggers heat shock protein expression in Chlamydomonas reinhardtii. Plant Cell Environ 40: 2987-3001

Schreiber D, Marx L, Felix S, Clasohm J, Weyland M, Schäfer M, Klotz M, Lilischkis R, Erkel G, Schäfer K-H (2017) Anti-inflammatory Effects of Fungal Metabolites in Mouse Intestine as Revealed by In vitro Models. Frontiers in Physiology 8

Schroda M, Grossman A (2017) Christoph Beck (1941-2017): a Chlamydomonas biologist. Photosynth Res 134: 231-232


Mackinder LC, Meyer MT, Mettler-Altmann T, Chen VK, Mitchell MC, Caspari O, Freeman Rosenzweig ES, Pallesen L, Reeves G, Itakura A, Roth R, Sommer F, Geimer S, Muhlhaus T, Schroda M, Goodenough U, Stitt M, Griffiths H, Jonikas MC (2016) A repeat protein links Rubisco to form the eukaryotic carbon-concentrating organelle. Proc Natl Acad Sci U S A 113: 5958-5963

Muranaka LS, Rutgers M, Bujaldon S, Heublein A, Geimer S, Wollman FA, Schroda M (2016) TEF30 interacts with photosystem II monomers and is involved in the repair of photodamaged photosystem II in Chlamydomonas reinhardtii. Plant Physiol 170: 821-840

Ramesh A, Peleh V, Martinez-Caballero S, Wollweber F, Sommer F, van der Laan M, Schroda M, Alexander RT, Campo ML, Herrmann JM (2016) A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import. J Cell Biol 214: 417-431

Tadini L, Pesaresi P, Kleine T, Rossi F, Guljamow A, Sommer F, Muhlhaus T, Schroda M, Masiero S, Pribil M, Rothbart M, Hedtke B, Grimm B, Leister D (2016) GUN1 controls accumulation of the plastid ribosomal protein S1 at the protein level and interacts with proteins involved in plastid protein homeostasis. Plant Physiol 170: 1817-1830

Takahashi H, Schmollinger S, Lee JH, Schroda M, Rappaport F, Wollman FA, Vallon O (2016) PETO Interacts with Other Effectors of Cyclic Electron Flow in Chlamydomonas. Mol Plant 9: 558-568

Tauber J, Rohr M, Walter T, Schollmeyer D, Rahn-Hotze K, Erkel G, Opatz T (2016) A surprising switch in absolute configuration of anti-inflammatory macrolactones. Org Biomol Chem 14: 3695-3698

Theis J, Schroda M (2016) Revisiting the photosystem II repair cycle. Plant Signal Behav 11: e1218587

Woellhaf MW, Sommer F, Schroda M, Herrmann JM (2016) Proteomic profiling of the mitochondrial ribosome identifies Atp25 as a composite mitochondrial precursor protein. Mol Biol Cell 27: 3031-3039


Barahimipour R, Strenkert D, Neupert J, Schroda M, Merchant SS, Bock R (2015) Dissecting the contributions of GC content and codon usage to gene expression in the model alga Chlamydomonas reinhardtii. Plant J

Bode M, Woellhaf MW, Bohnert M, van der Laan M, Sommer F, Jung M, Zimmermann R, Schroda M, Herrmann JM (2015) Redox-regulated dynamic interplay between Cox19 and the copper-binding protein Cox11 in the intermembrane space of mitochondria facilitates biogenesis of cytochrome c oxidase. Molecular Biology of the Cell 26: 2385-2401

Bollmann F, Jackel S, Schmidtke L, Schrick K, Reinhardt C, Jurk K, Wu Z, Xia N, Li H, Erkel G, Walter U, Kleinert H, Pautz A (2015) Anti-Inflammatory and Anti-Thrombotic Effects of the Fungal Metabolite Galiellalactone in Apolipoprotein E-Deficient Mice. PLoS One 10: e0130401

Hemme D, Surulescu C, Becker HM, Deitmer JW, Mühlhaus T, Garth C, Schroda M (2015) BioComp - Analyse komplexer Datensätze in Lebenswissenschaften und Biotechnologie. Systembiologie.de 9: 68-71

Jung B, Ludewig F, Schulz A, Meissner G, Wostefeld N, Flugge UI, Pommerrenig B, Wirsching P, Sauer N, Koch W, Sommer F, Muhlhaus T, Schroda M, Cuin TA, Graus D, Marten I, Hedrich R, Neuhaus HE (2015) Identification of the transporter responsible for sucrose accumulation in sugar beet taproots. Nat Plants 1: 14001

Richter J, Sandjo LP, Liermann JC, Opatz T, Erkel G (2015) 4-Dechloro-14-deoxy-oxacyclododecindione and 14-deoxy-oxacylododecindione, two inhibitors of inducible connective tissue growth factor expression from the imperfect fungus Exserohilum rostratum. Bioorg Med Chem 23: 556-563

Schroda M, Hemme D, Muhlhaus T (2015) The Chlamydomonas heat stress response. Plant J 82: 466-480

Tauber J, Rohr M, Walter T, Erkel G, Opatz T (2015) Total synthesis of two potent anti-inflammatory macrolactones of the oxacyclododecindione type. Org Biomol Chem 13: 7813-7821

Trosch R, Muhlhaus T, Schroda M, Willmund F (2015) ATP-dependent molecular chaperones in plastids--More complex than expected. Biochim Biophys Acta 1847: 872-888


Felix S, Sandjo LP, Opatz T, Erkel G (2014) Anti-inflammatory drimane sesquiterpene lactones from an Aspergillus species. Bioorg Med Chem 22: 2912-2918

Hemme D, Veyel D, Muhlhaus T, Sommer F, Juppner J, Unger AK, Sandmann M, Fehrle I, Schonfelder S, Steup M, Geimer S, Kopka J, Giavalisco P, Schroda M (2014) Systems-wide analysis of acclimation responses to long-term heat stress and recovery in the photosynthetic model organism Chlamydomonas reinhardtii. Plant Cell 26: 4270-4297

Henke J, Erkel G, Brochhausen C, Kleinert H, Schwarting A, Menke J, Pautz A (2014) The fungal lactone oxacyclododecindione is a potential new therapeutic substance in the treatment of lupus-associated kidney disease. Kidney Int 86: 780-789

Langhanki J, Rudolph K, Erkel G, Opatz T (2014) Total synthesis and biological evaluation of the natural product (-)-cyclonerodiol, a new inhibitor of IL-4 signaling. Org Biomol Chem 12: 9707-9715

Lohse M, Nagel A, Herter T, May P, Schroda M, Zrenner R, Tohge T, Fernie AR, Stitt M, Usadel B (2014) Mercator: a fast and simple web server for genome scale functional annotation of plant sequence data. Plant Cell Environ 37: 1250-1258

Mettler T, Muhlhaus T, Hemme D, Schottler MA, Rupprecht J, Idoine A, Veyel D, Pal SK, Yaneva-Roder L, Winck FV, Sommer F, Vosloh D, Seiwert B, Erban A, Burgos A, Arvidsson S, Schonfelder S, Arnold A, Gunther M, Krause U, Lohse M, Kopka J, Nikoloski Z, Mueller-Roeber B, Willmitzer L, Bock R, Schroda M, Stitt M (2014) Systems analysis of the response of photosynthesis, metabolism, and growth to an increase in irradiance in the photosynthetic model organism Chlamydomonas reinhardtii. Plant Cell 26: 2310-2350

Ramundo S, Casero D, Muhlhaus T, Hemme D, Sommer F, Crevecoeur M, Rahire M, Schroda M, Rusch J, Goodenough U, Pellegrini M, Perez-Perez ME, Crespo JL, Schaad O, Civic N, Rochaix JD (2014) Conditional depletion of the Chlamydomonas chloroplast ClpP protease activates nuclear genes involved in autophagy and plastid protein quality control. Plant Cell 26: 2201-2222

Schmollinger S, Muhlhaus T, Boyle NR, Blaby IK, Casero D, Mettler T, Moseley JL, Kropat J, Sommer F, Strenkert D, Hemme D, Pellegrini M, Grossman AR, Stitt M, Schroda M, Merchant SS (2014) Nitrogen-sparing mechanisms in Chlamydomonas affect the transcriptome, the proteome, and photosynthetic metabolism. Plant Cell 26: 1410-1435

Sommer F, Muhlhaus T, Hemme D, Veyel D, Schroda M (2014) Identification and validation of protein-protein interactions by combining co-immunoprecipitation, antigen competition, and stable isotope labeling. Methods Mol Biol 1188: 245-261

Trösch R, Schroda M, Willmund F (2014) Molecular Chaperone Functions in Plastids. In SM Theg, F-A Wollman, eds, Plastid Biology, Vol 5. Springer New York, pp 325-357

Veyel D, Erban A, Fehrle I, Kopka J, Schroda M (2014) Rationales and approaches for studying metabolism in eukaryotic microalgae. Metabolites 4: 184-217

Veyel D, Sommer F, Muranaka LS, Rutgers M, Lemaire SD, Schroda M (2014) In vitro characterization of bacterial and chloroplast Hsp70 systems reveals an evolutionary optimization of the co-chaperones for their Hsp70 partner. Biochem J 460: 13-24


Felix S, Sandjo LP, Opatz T, Erkel G (2013) SF002-96-1, a new drimane sesquiterpene lactone from an Aspergillus species, inhibits survivin expression. Beilstein J Org Chem 9: 2866-2876

Rudolph K, Serwe A, Erkel G (2013) Inhibition of TGF-beta signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone. Cytokine 61: 285-296

Rutgers M, Schroda M (2013) A role of VIPP1 as a dynamic structure within thylakoid centers as sites of photosystem biogenesis? Plant Signal Behav 8: e27037

Schmollinger S, Schulz-Raffelt M, Strenkert D, Veyel D, Vallon O, Schroda M (2013) Dissecting the heat stress response in Chlamydomonas by pharmaceutical and RNAi approaches reveals conserved and novel aspects. Mol Plant 6: 1795-1813

Strenkert D, Schmollinger S, Schroda M (2013) Heat shock factor 1 counteracts epigenetic silencing of nuclear transgenes in Chlamydomonas reinhardtii. Nucleic Acids Res 41: 5273-5289


Nordhues A, Schottler MA, Unger AK, Geimer S, Schonfelder S, Schmollinger S, Rutgers M, Finazzi G, Soppa B, Sommer F, Muhlhaus T, Roach T, Krieger-Liszkay A, Lokstein H, Crespo JL, Schroda M (2012) Evidence for a role of VIPP1 in the structural organization of the photosynthetic apparatus in Chlamydomonas. Plant Cell 24: 637-659

Schmidt N, Art J, Forsch I, Werner A, Erkel G, Jung M, Horke S, Kleinert H, Pautz A (2012) The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis. J Pharmacol Exp Ther 343: 106-114

Schmollinger S, Strenkert D, Offeddu V, Nordhues A, Sommer F, Schroda M (2012) A protocol for the identification of protein-protein interactions based on 15N metabolic labeling, immunoprecipitation, quantitative mass spectrometry and affinity modulation. J Vis Exp

Schreiber D, Jung M, Sandjo LP, Liermann JC, Opatz T, Erkel G (2012) 3'-Demethyldihydromaldoxin and dihydromaldoxin, two anti-inflammtory diaryl ethers from a Steganospora species. J Antibiot (Tokyo) 65: 473-477

Serwe A, Rudolph K, Anke T, Erkel G (2012) Inhibition of TGF-beta signaling, vasculogenic mimicry and proinflammatory gene expression by isoxanthohumol. Invest New Drugs 30: 898-915


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