Fachgebiet Molekulare Biotechnologie & Systembiologie

Professor of Molecular Biotechnology & Systems Biology

Contact:

Molecular Biotechnology & Systems Biology
TU Kaiserslautern
Paul-Ehrlich-Straße 23, Room 103
67663 Kaiserslautern

Tel.: +49 (0)631-205-2697

Email: schroda[at]bio.uni-kl.de
Profile: Google Scholar


Curriculum Vitae:

since 2011: Professor (Chair) of Molecular Biotechnology & Systems Biology at the TU Kaiserslautern

2008-2011: Group leader at the Max-Planck-Institute of Molecular Plant Physiology in Potsdam-Golm

2003-2008: Junior Professor at the Department of Plant Biochemistry, University of Freiburg

2001-2003: Staff scientist at the Department of Plant Biochemistry, University of Freiburg

1999-2001: Postdoctoral fellow at the IBPC Paris, France

1994-1999: PhD in Molecular Genetics, Dept. of Biology III, University of Freiburg, Germany

1988-1994: Study of Biology at the Universities of Marburg, Tennessee and Helsinki

2015-2018: Dean of the Faculty of Biology

since 2014: Speaker of the Forschungsschwerpunkt BioComp, TU Kaiserslautern

since 2011: Vertrauensdozent of the Friedrich-Ebert-Stiftung


Major Research Interests:

In our research we want to understand how protein homeostasis is ensured in the cytosolic and chloroplast compartments of a plant cell. For this, we study the players involved in protein homeostasis, i.e. chaperones and proteases, in both compartments, and the signaling pathways involved to ensure homeostasis. Furthermore, we investigate how thylakoid membranes and the protein complexes therein are formed and maintained.
These questions are addressed with systems biology approaches largely involving mass spectrometry-based quantitative proteomics.
Moreover, we use synthetic biology (Modular Cloning) to engineer Chlamydomonas in order to address our basic research questions and to endow this organism with new properties for applied research. 


Selected Publications:

Crozet, P., Navarro, F.J., Willmund, F., Mehrshahi, P., Bakowski, K., Lauersen, K.J., Perez-Perez, M.E., Auroy, P., Gorchs Rovira, A., Sauret-Gueto, S., Niemeyer, J., Spaniol, B., Theis, J., Trosch, R., Westrich, L.D., Vavitsas, K., Baier, T., Hubner, W., de Carpentier, F., Cassarini, M., Danon, A., Henri, J., Marchand, C.H., de Mia, M., Sarkissian, K., Baulcombe, D.C., Peltier, G., Crespo, J.L., Kruse, O., Jensen, P.E., Schroda, M., Smith, A.G., and Lemaire, S.D. (2018). Birth of a photosynthetic chassis: a MoClo toolkit enabling synthetic biology in the microalga Chlamydomonas reinhardtii. ACS synthetic biology, 7, 2074-2086.

 

Rutgers M, Muranaka LS, Schulz-Raffelt M, Thoms S, Schurig J, Willmund F, Schroda M (2017) Not changes in membrane fluidity but proteotoxic stress triggers heat shock protein expression in Chlamydomonas reinhardtii. Plant Cell Environ, 40: 2987-3001.

 

Muranaka, L. S., Rutgers, M., Bujaldon, S., Heublein, A., Geimer, S., Wollman, F. A. and Schroda, M. (2016) TEF30 Interacts with Photosystem II Monomers and Is Involved in the Repair of Photodamaged Photosystem II in Chlamydomonas reinhardtii. Plant Physiol 170: 821-840

 

Hemme D, Veyel D, Muhlhaus T, Sommer F, Juppner J, Unger AK, Sandmann M, Fehrle I, Schonfelder S, Steup M, Geimer S, Kopka J, Giavalisco P, Schroda M (2014) Systems-wide analysis of acclimation responses to long-term heat stress and recovery in the photosynthetic model organism Chlamydomonas reinhardtii. Plant Cell 26:4270-4297

 

Schmollinger S, Muhlhaus T, Boyle NR, Blaby IK, Casero D, Mettler T, Moseley JL, Kropat J, Sommer F, Strenkert D, Hemme D, Pellegrini M, Grossman AR, Stitt M, Schroda M, Merchant SS (2014) Nitrogen-sparing mechanisms in Chlamydomonas affect the transcriptome, the proteome and photosynthetic metabolism. Plant Cell 26: 1410-1435

 

Schmollinger S, Schulz-Raffelt M, Strenkert D, Veyel D, Vallon O, Schroda M (2013) Dissecting the heat stress response in Chlamydomonas by pharmaceutical and RNAi approaches reveals conserved and novel aspects. Mol Plant 6: 1795-1813

 

Strenkert D, Schmollinger S, Schroda M (2013) Heat shock factor 1 counteracts epigenetic silencing of nuclear transgenes in Chlamydomonas reinhardtii. Nucleic Acids Res 41: 5273-5289

 

Nordhues A, Schöttler MA, Unger AK, Geimer S, Schönfelder S, Schmollinger S, Rütgers M, Finazzi G, Soppa B, Sommer F, Mühlhaus T, Roach T, Krieger-Liszkay A, Lokstein H, Crespo JL, Schroda M (2012) Evidence for a role of VIPP1 in the structural organization of the photosynthetic apparatus in Chlamydomonas. Plant Cell 24: 637-659

 

Mühlhaus T, Weiss J, Hemme D, Sommer F, Schroda M (2011) Quantitative shotgun proteomics using a uniform 15N-labeled standard to monitor proteome dynamics in time course experiments reveals new insights into the heat stress response of Chlamydomonas reinhardtii. Mol Cell Proteomics 10: M110 004739

 

Strenkert D, Schmollinger S, Sommer F, Schulz-Raffelt M, Schroda M (2011) Transcription factor dependent chromatin remodeling at heat shock and copper responsive promoters in Chlamydomonas reinhardtii. Plant Cell 23: 2285-2301

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