Fachgebiet Molekulare Genetik

2022

  • Bernhard SV, Seget-Trzensiok K, Kuffer C, Krastev DB, Stautmeister LM, Theis M, Keuper K, Boekenkamp JE, Kschischo M, Buchholz F, Storchova Z (2022) Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling Cell Oncol (Dordr) 2022 Feb;45(1):103-119.
    doi: 10.1007/s13402-021-00654-5. Epub 2021 Dec 28
     
  • Yahya G, Menges P, Amponsah PS, Ngandiri DA, Schulz D, Wallek A, Kulak N, Mann M, Cramer P, Savage V, Räschle M, Storchova Z (2022) Sublinear scaling of the cellular proteome with ploidy Nat Commun 2022 Oct 19;13(1):6182.
    doi: 10.1038/s41467-022-33904-7
     
  • Rödl S, den Brave F, Räschle M, Kizmas B, Lenhard S, Groh C, Becker H, Zimmermann J, Morgan B, Richling E, Becker T, Herrmann JM (2022) The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import Life Sci Alliance 2022 Oct 17;6(1):e202201526.
    doi: 10.26508/lsa.202201526. Print 2023 Jan
     
  • Glueck D, Grethen A, Das M, Mmeka OP, Patallo EP, Meister A, Rajender R, Kins S, Räschle M, Victor J, Chu C, Etzkorn M, Köck Z, Bernhard F, Babalola JO, Vargas C, Keller S (2022) Electroneutral Polymer Nanodiscs Enable Interference-Free Probing of Membrane Proteins in a Lipid-Bilayer Environment Small 2022 Oct 13;e2202492.
    doi: 10.1002/smll.202202492. Online ahead of print.
     
  • Trösch R, Ries F, Westrich LD, Gao Y, Herkt C, Hoppstädter J, Heck-Roth J, Mustas M, Scheuring D, Choquet Y, Räschle M, Zoschke R, Willmund F (2022) Fast and global reorganization of the chloroplast protein biogenesis network during heat acclimation Plant Cell 2022 Mar 4;34(3):1075-1099.
    doi: 10.1093/plcell/koab317.
     
  • Gönenc II, Wolff A, Schmidt J, Zibat A, Müller C, Cyganek L, Argyriou L, Räschle M, Yigit G, Wollnik B (2022) Single-cell transcription profiles in Bloom syndrome patients link BLM deficiency with altered condensin complex expression signatures Hum Mol Genet 2022 Jul 7;31(13):2185-2193. doi: 10.1093/hmg/ddab373
     
  • Chunduri NK, Barthel K, Storchova Z (2022) Consequences of Chromosome Loss: Why Do Cells Need Each Chromosome Twice? Cells 2022 May 3;11(9):1530.
    doi: 10.3390/cells11091530
     
  • Prasad K, Bloomfield M, Levi H, Keuper K, Bernhard SV, Baudoin NC, Leor G, Eliezer Y, Giam M, Wong CK, Rancati G, Storchova Z, Cimini D, Ben-David U (2022) Whole-Genome Duplication Shapes the Aneuploidy Landscape of Human Cancers. Cancer Res 2022 May 3;82(9):1736-1752.
    doi: 10.1158/0008-5472.CAN-21-2065
     
  • Gemble S, Wardenaar R, Keuper K, Srivastava N, Nano M, Mace AS, Tijhuis AE, Bernhard SV, Spierings DCJ, Simon A, Goundiam O, Hochegger H, Piel M, Foijer F, Storchova Z, Basto R (2022) Genetic instability from a single S phase after whole-genome duplication. Nature 2022 Apr;604(7904):146-151.
    doi: 10.1038/s41586-022-04578-4. Epub 2022 Mar 30
    Author Correction: Genetic instability from a single S phase after whole-genome duplication Published Erratum Nature 2022 Aug;608(7923):E27. doi: 10.1038/s41586-022-05099-w.

 

2021

  • Taschner M, Basquin J, Steigenberger B, Schäfer IB, Soh YM, Basquin C, Lorentzen E, Räschle M, Scheltema RA, Gruber S (2021) Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding. EMBO J. 2021 Aug 2;40(15):e107807
    doi: 10.15252/embj.2021107807. Epub 2021 Jun 30.PMID:34191293
     
  • Chunduri NK, Menges P, Zhang X, Wieland A, Gotsmann VL, Mardin BR, Buccitelli C, Korbel JO, Willmund F, Kschischo M, Raeschle M, Storchová Z (2021) Systems approaches identify the consequences of monosomy in somatic human cells. Nature Communications 12:5576
    doi: 10.1038/s41467-021-25288-x
     
  • Keuper K, Wieland A, Räschle M, Storchová Z (2021) Processes shaping cancer genomes – From mitotic defects to chromosomal rearrangements. DNA Repair 107:103207
    doi: 10.1016/j.dnarep.2021.103207
     
  • Lukow DA, Sausville EL, Suri P, Chunduri NK, Wieland A, Leu L, Smith JC, Kendall J, Wang Z, Storchova Z, Sheltzer JM (2021) Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies. Developmental Cell 56:2427-2439
    doi: 10.1016/j.devcel.2021.07.009
     
  • Krivega M, Stiefel CM, Karbassi S, Andersen LL, Chunduri NK, Donnelly N, Pichlmair A, Storchová Z (2021) Genotoxic stress in constitutive trisomies induces authophagy and the innate immune response via the cGAS-STING pathway. Communications Biology 4(1): 831
    doi.org/10.1038/s42003-021-02278-9
     
  • Cohen-Sharir Y, McFarland JM, Abdusamad M, Marquis C, Bernhard SV, Kazachkova M, Tang H, Ippolito MR, Laue K, Zerbib J, Malaby HLH, Jones A, Stautmeister L-M, Bockaj I, Wardenaar R, Lyons N, Nagaraja A, Bass AJ, Spierings DCJ, Foijer F, Beroukhim R, Santaguida S, Golub TR, Stumpff J, Storchová Z, Ben-David U (2021) Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition . Nature 590, pages486–491
    https://dx.doi.org/10.1038/s41586-020-03114-6
     
  • Amponsah PS, Yahya G, Zimmermann J, Mai M, Mergel S, Molin M, Mühlhaus T, Storchová Z, Morgan B (2021) Peroxiredoxins couple metabolism and cell division in an ultradian cycle. Nature Chemical Biology
    https://doi.org/10.1038/s41589-020-00728-9
     
  • Westrich LD, Gotsmann VL, Herkt C, Ries F, Kazek T, Trösch R, Ramundo S, Nickelsen J, Armbruster L, Wirtz M, Finkemeier I, Storchová Z, Raeschle M, Willmund F (2021) The versatile interactome of chloroplast ribosomes revealed by affinity purification mass spectrometry. NAR; 49(1):400-415
    https://doi.org/10.1093/nar/gkaa1192

2020

  • Yahya G, Wu Y, Peplowska K, Röhrl J, Soh Y-M, Bürmann F, Gruber S, Storchová Z (2020) Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast.PLoS Genet. 2020 Aug 18;16(8): e1008569
    https://doi.org/10.1371/journal.pgen.1008569

  • Yim A, Koti P, Bonnard A, Marchiano F, Dürrbaum M, Garcia-Perez C, Villaveces J, Gamal S, Cardone G, Perocchi F, Storchova Z, Habermann BH (2020) mitoXplorer, a visual data mining platform to systematically analyze and visualize mitochondrial expression dynamics and mutations. Nucleic Acids Res. 48(2):605-632
    https://doi.org/10.1093/nar/gkz1128

  • Vasudevan A, Baruah PS, Smith JC, Wang Z, Sayles NM, Andrews P, Kendall J, Leu J, Chunduri NK, Levy D, Wigler M, Storchová Z, Sheltzer JM (2020) Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer. Developmental Cell 52(2), 413-428.
    http://doi.org/10.1016/j.devcel.2020.01.034

  • Schukken KM, Lin YC, Bakker PL, Schubert M, Preuss SF, Simon JE, van den Bos H, Storchová Z, Colomé-Tatché M, Bastians H, Spierings DC, Foijer F (2020) Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition. Life Sci Alliance: 3(2). pii: e201900499.
    http://doi.org/10.26508/lsa.201900499

2019

  • Kneissig M, Keuper K, de Pagter MS, van Roosmalen MJ, Martin J, Otto H, Passerini V, Campos Sparr A, Renkens I, Kropveld F, Vasudevan A, Sheltzer JM, Klosterman WP, Storchova Z. Micronuclei-based model system reveals functional consequences of chromothripsis in human cells. Elife (2019) 8. pii:e50292.
    http://doi.org/10.7554/eLife.50292

  • Yim A, Koti P, Bonnard A, Marchiano F, Dürrbaum M, Garcia-Perez C, Villaveces J, Gamal S, Gardone G, Perocchi F, Storchova Z, Habermann BH. mitoXplorer, a visual data mining platform to systematically analyze and visualize mitochondrial expression dynamics and mutations. Nucleic Acids Res (2019). pii: gkz1128.
    http://doi.org/10.1093/nar/gkz1128

  • Hwang S, Williams JF, Kneissig M, Lioudyno M, Rivera I, Helguera P, Busciglio J, Storchova Z, King MC, Torres EM. Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells. Cell Rep. (2019): 29:2473-2488.e5
    http://doi.org/10.1016/j.celrep.2019.10.059

  • Kneissig M, Bernhard S, Storchova Z. Modelling chromosome structural and copy number changes to understand cancer genomes. Curr Opin Genet Dev. (2019): Feb;54:25-32
    http://doi.org/10.1016/j.gde.2019.02.005

  • Brennan CM, Vaites LP, Wells JN, Santaguida S, Paulo JA, Storchova Z, Harper JW, Marsh JA, Amon A. Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells. Genes Dev. (2019): 1;33(15-16):1031-1047
    http://doi.org/10.1101/gad.327494.119

  • Larsen NB , Gao OA, Sparks JL, Gallina I, Wu AR, Mann M, Räschle M, Walter JC, Duxin J. Replication-coupled DNA-protein crosslink repair by SPRTN and the Proteasome in Xenopus egg extracts. Mol. Cell (2019): 18:30994
    http://doi.org/10.1016/j.molcel.2018.11.024

  • Sparks JL, Chistol G, Gao AO, Räschle M, Walter JC, Duxin J. The CMG helicase bypasses DNA-protein crosslinks to facilitate their repair. Cell (2019): Jan;176(1-2):167-182
    http://doi.org/10.1016/j.cell.2018.10.053

  • Chunduri NK, Storchova Z. The diverse consequences of aneuploidy. Nat Cell Biol. (2019): Jan;21(1):54-6
    http://doi.org/10.1038/s41556-018-0243-8

 

 


2018

  • Dürrbaum M, Kruse C, Nieken KJ, Habermann B, Storchová Z (2018) The deregulated microRNAome contributes to the cellular response to aneuploidy. BMC Genomics 19:197;
    https://doi.org/10.1186/s12864-018-4556-6
  • Viganó C, von Schubert C, Ahrné E, Schmidt A, Lorber T, Bubendorf L, De Vetter JRF, Zaman GJR, Storchova Z, Nigg EA. Quantitative proteomic and phospho-proteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability. Mol Biol Cell. (2018).
    http://doi.org/10.1091/mbc.E17-10-0577


2017

  • Sheltzer JM, Ko J, Habibe Burgos NC, Chung E, Meehl CM, Passerini V, Storchová Z, Amon A. Single-chromosome aneuploidy commonly functions as a tumor suppressor, Cancer Cell (2017):31:240-255.
    https://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30599-2

  • Libouban MAA, de Roos JADM, Uitdehaag JCM, Willemsen-Seegers N, Mainardi S, Dylus J, de Man J, Tops B, Meijerink JPP, Storchová Z, Buijsman RC, Medema RH, Zaman GJR. Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines. Oncotarget (2017): 8:38309-38325.
    http://doi.org/10.18632/oncotarget.16213

  • Domingues PH, Nanduri LS, Seget K, Venkateswaran SV, Agorku D, Viganó C, von Schubert C, Nigg EA, Swanton C, Sotillo R, Bosio A, Storchová Z, Hardt O. Cellular prion protein PRPC and ecto-5'-nucleotidase are markers of the cellular stress response to aneuploidy. Cancer Res.  (2017): 77: 2914-2926.
    http://doi.org/10.1158/0008-5472.CAN-16-3052


2016

  • Storchová Z. Too much to differentiate: aneuploidy promotes proliferation and teratoma formation in embryonic stem cells. EMBO J.(2016): e201695486.
    http://doi.org/10.15252/embj.201695486

  • McShane E, Sin C, Zauber H, Wells J, Donnelly N, Wang X, Hou Y, Chen W, Storchová Z, Marsh J, Valeriani A and Selbach M. Kinetic Analysis of Protein Stability Reveals Age-Dependent Degradation. Cell (2016):167:803-815
    http://doi.org/10.1016/j.cell.2016.09.015

  • Passerini V, Storchová Z. Too much to handle - how gaining chromosomes destabilizes the genome. Cell Cycle (2016): 16:1-8.
    http://doi.org/10.1080/15384101.2016.1231285

  • Storchová Z, Kloosterman WP. The genomic characteristics and cellular origin of chromothripsis, Curr Opin Cell Biol. (2016): 40:106-13.
    http://doi.org/10.1016/j.ceb.2016.03.003

  • Passerini V, Ozeri-Galai E, de Pagter MS, Donnelly N, Schmalbrock S, Kloosterman WP, Kerem B, Storchová Z. The presence of extra chromosomes leads to genomic instability, Nat Commun. (2016): 7:10754.
    http://doi.org/10.1038/ncomms10754

  • Lamm N, Ben-David U, Golan-Lev T, Storchová Z, Benvenisty Z, Kerem B. Genomic instability in human pluripotent stem cells arises from replicative stress and chromosome condensation defects, Cell Stem Cell (2016): 18: 253-61.
    http://doi.org/10.1016/j.stem.2015.11.003

  • Klionsky DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016):12:1-222.
    http://doi.org/10.1080/15548627.2015.1100356


2015

  • Dürrbaum M, Storchová Z. Effects of aneuploidy on gene expression: implications for cancer, FEBS J. (2015): 283: 791-802; doi: 10.1111/febs.13591.

  • Kuznetsova AY, Seget K, Moeller GK, de Pagter MS, de Roos JADM, Dürrbaum M, Kuffer C, Müller S, Zaman GJR, Kloosterman WP, Storchová Z. Whole genome doubling promotes chromosomal instability, tolerance of mitotic errors and multidrug resistance, Cell Cycle (2015): 14: 2810-20.

  • Räschle M, Hansen RK, Smeenk G, Temu T, Hein MY, Nagaraj N, Oka Y, Long DT, Schmalbrock S, Walter JC, Storchová Z, Hofmann K, Bekker-Jensen S, Mailand N, Mann M. Time-resolved proteomics of ICL repair reveals a SMC5/6 recruitment pathway, Science (2015): 348:1253671.

  • Donnelly N, Storchová Z. Causes and consequences of protein folding stress in aneuploid cells, Cell Cycle (2015): 14(4), 495-501.

  • Donnelly N, Storchová Z. Aneuploidy and proteotoxic stress in cancer, Molecular & Cellular Oncology (2015): 2: e976491.


2014

Donnelly N, Passerini V, Dürrbaum M, Stingele S, Storchová Z (2014) HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells, EMBO Journal 33:2374-87.

Peplowska K, Wallek AU, Storchová Z (2014) Sgo1 Regulates both Condensin and Ipl1/Aurora B to Promote Chromosome Biorientation, PLoS Genet. 10: e1004411.

Storchová Z (2014) Ploidy changes and genome stability in yeast, Yeast 31:421-30. doi: 10.1002/yea.3037.

Dürrbaum M, Kuznetsova AY, Passerini V, Stingele S, Stoehr G, Storchová Z (2014) Unique features of the transcriptional response to model aneuploidy in human cells. BMC Genomics 2014, 15:139 - 52.

Donnelly N, Storchová Z (2014) Dynamic karyotype, dynamic proteome: Buffering the effects of aneuploidy. Biochim Biophys Acta.1843:473-81.

 

2013

Hahn M, Dambacher S, Dulev S, Kuznetsova AY, Eck S, Wörz S, Sadic D, Schulte M, Mallm J-P, Schermelleh L, Debs P, von Melchner H, Leonhardt H, Rohr K, Rippe K, Storchová Z, Schotta G. Chromatin compaction by Suv4-20h2 is essential for cohesin recruitment to heterochromatin, Genes Dev. (2013): 27:859-72.

Kuffer C, Kuznetsova AY, Storchová Z.  Defective mitosis triggers the p53-dependent cell cycle arrest in human tetraploid cells, Chromosoma (2013):122: 305-318.

Shaposhnikov D, Kuffer C, Storchová Z, Posern G. Myocardin related transcription factors are required for coordinated cell cycle progression, Cell Cycle (2013): 12: 1762-72.

Stingele S, Stoehr G, Storchová Z. Activation of autophagy in cells with abnormal karyotype, Autophagy (2013): 9:246-248.


2012

Stingele S, Stoehr G, Peplowska K, Cox J, Mann M, Storchová Z. Global analysis of genome, transcriptome and proteome reveals cellular response to aneuploidy, Molecular Systems Biology (2012): 8: 608.

Stephan D, Sánchez-Soriano N, Loschek L, Gutmann S, Storchová Z, Prokop A, Grunwald Kadow I.  Drosophila Psidin is required for neurogenesis and axon targeting through two distinct molecular mechanisms, Journal of Neuroscience, J. Neurosci (2012):32: 16080 – 16094.

Hüls D, Storchová Z, Niessing D. Posttranslational modifications regulate assembly of the early spindle-orientation complex in yeast, J. Biol. Chemistry(2012): ‎ 287: 16238-45.

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