Professor of Molecular Genetics
since 2016: Professor of Molecular Genetics, Department of Biology, University Kaiserslautern, Germany.
2008-2016: Group Leader, Max-Plack Institute of Biochemistry, Martinsried, Germany.
2001-2007: Postdoc, Dana-Farber Cancer Institute/Harvard Medical School, Boston, USA.
1999-2001: Postdoc, Institute of Medical Radiobiology, University of Zurich, Switzerland.
1995-1999: Ph.D. Studies, Dept. of Genetics and Microbiology, Charles University, Prague, Czech Republic.
Major Research Interests:
The research of our group focuses on understanding how changes in chromosome numbers and structure affect cellular functions. The genome integrity is essential for healthy survival and altered chromosome structure and numbers are associated with pathologies, such as developmental defects or cancer. We create human cell lines with aberrant chromosomes and use a broad range of biochemistry, cell biology and -omics methods to determine the effects of these changes on cellular physiology and the links to disease. Moreover, using quantitative proteomics and phosphoproteomics, we determine the execution and regulation of processes required for DNA replication, repair and chromosome segregation. research pages
Viganó C, von Schubert C, Ahrné E, Schmidt A, Lorber T, Bubendorf L, De Vetter JRF, Zaman GJR, Storchová Z, Nigg EA. (2018) Quantitative proteomic and phospho-proteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability. Mol Biol Cell. 29:1031-1047.
Sheltzer JM, Ko J, Habibe Burgos NC, Chung E, Meehl CM, Passerini V, Storchová Z, Amon (2017) Single-chromosome aneuploidy commonly functions as a tumor suppressor, Cancer Cell, 31:240-255.
Passerini V, Ozeri-Galai E, de Pagter MS, Donnelly N, Schmalbrock S, Kloosterman WP, Kerem B, Storchová Z (2016) The presence of extra chromosomes leads to genomic instability, Nat Commun. 7:10754. doi: 10.1038/ncomms10754.
Kuznetsova AY, Seget K, Moeller GK, de Pagter MS, de Roos JADM, Dürrbaum M, Kuffer C, Müller S, Zaman GJR, Kloosterman WP, Storchová Z (2015) Whole genome doubling promotes chromosomal instability, tolerance of mitotic errors and multidrug resistance, Cell Cycle 14: 2810-20.
Räschle M, Hansen RK, Smeenk G, Temu T, Hein MY, Nagaraj N, Oka Y, Long DT, Schmalbrock S, Walter JC, Storchová Z, Hofmann K, Bekker-Jensen S, Mailand N, Mann M (2015) Time-resolved proteomics of ICL repair reveals a SMC5/6 recruitment pathway, Science 348:1253671.
Stingele S, Stoehr G, Peplowska K, Cox J, Mann M, Storchová Z (2012) Global analysis of genome, transcriptome and proteome reveals cellular response to aneuploidy, Molecular Systems Biology 8: 608.
Chunduri NK, Storchová Z. (2019) The diverse consequences of aneuploidy. Nat Cell Biol. 21:54-62.