Professor of Animal Physiology
1987: Dr. rer. nat (Ph.D.) University of Tübingen
1987-1989 Postdoctoral fellow with Carla Shatz at Stanford University, USA
1993 Habilitation (Animal Physiology), University of Tübingen
1995-1999 Professor of Physiology, Department of Medicine, University of Frankfurt
since 1999 Professor of Animal Physiology/Neurobiology, Department of Biology, University of Kaiserslautern, Head of the Animal Physiology Group
2003-2005 Head of the Department of Biology (Dekan), University of Kaiserslautern
2004 Offer of a Professorship for Physiology, Department of Medicine, University of Frankfurt, declined.
Major Research Interest:
The human brain is composed of almost a hundred billion (1011) neurons, and each neuron may be connected to about 1,000 (103) fellow neurons. The complexity and the precision of connectivity determine the proper function of the brain. The major aim of research in our laboratory is to elucidate the mechanisms that establish this precision during ontogeny and maintain it throughout life. Our experiments focus on the mammalian central auditory system, which consists of several relay stations displaying a great number of excitatory and inhibitory connections. We are interested in the molecular components that specify these auditory connections, which function with a remarkable temporal precision in the microsecond range. In our current approaches, we study auditory brainstem circuits in rats and mice employing physiological, anatomical, and biochemical techniques, including proteomics.
Selected Recent Publications:
- Moritz CP, Mühlhaus MH, Tenzer S, Schulenborg T, Friauf E (2019) Poor transcript-protein correlation in the brain: negatively correlating gene products reveal neuronal polarity as a potential cause. J Neurochem.
- Beiderbeck B, Myoga MH, Müller NIC, Callan AR, Friauf E, Grothe B, Pecka M (2018) Precisely timed inhibition facilitates action potential firing for spatial coding in the auditory brainstem. Nat Commun 9:1771.
- Krächan EG, Fischer AU, Franke J, Friauf E (2017) Synaptic reliability and temporal precision are achieved via high quantal content and effective replenishment: auditory brainstem versus hippocampus. J Physiol 595:839-864.
- Moritz CP, Eckstein E, Tenzer S, Friauf E (2015) Neuroproteomics in the Auditory Brainstem: Candidate Proteins for Ultrafast and Precise Information Processing. Mol Cell Neurosci. 64:9-23.
- Fritzsch B, Knipper M, Friauf E (2015) Auditory system: development, genetics, function, aging, and diseases. Cell Tissue Res. 361:1-6.
- Friauf E, Fischer AU, Fuhr MF (2015) Synaptic plasticity in the auditory system: a review. Cell Tissue Res. 361:177-213.
- Ebbers L, Satheesh SV, Janz K, Rüttiger L, Blosa M, Hofmann F, Morawski M, Griesemer D, Knipper M, Friauf E, Nothwang HG (2015) L-type Calcium Channel Cav1.2 Is Required for Maintenance of Auditory Brainstem Nuclei. J Biol Chem. 290:23692-23710.
- Stephan J, Friauf E (2014) Functional Analysis in the inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 in astrocytes of the lateral superioer olive. Glia 62:1992-2003.
- Pirone A, Kurt S, Zuccotti A, Rüttiger L, Pilz P, Brown DH, Franz C, Schweizer M, Rust MB, Rübsamen R, Friauf E, Knipper M, Engel J (2014) α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders. J Neurosci. 34:434-445.
- Moritz CP, Marz SX, Reiss R, Schulenborg T, Friauf E (2014) Epicocconone staining: a powerful loading control for Western blots. Proteomics 14:162-168.
Detailed list of publications