In the DFG research group FOR2800, scientists from five German universities located in Göttingen, Kaiserslautern, Koblenz, Mainz and Mannheim/Heidelberg work together to study the origin of chromosome instability in human cells. In two independent projects groups from the Molecular Genetics department address how replication stress caused by aneuploidy affects chromosome segregation (Group Storchova) and how mitotic DNA repair pathways mitigate segregation problems (Group Räschle). They combine high resolution microscopy and next generation sequencing to characterize the molecular mechanisms and the consequences of replication stress. Using quantitative mass spectrometry they aim to identify the key players of mitotic DNA repair pathways critical for genomic stability in human cells.
DFG Research Group FOR2800
BioComp is a multidisciplinary research initiative with participating scientists from Biology, Chemistry, Physics, Informatics, Mathematics and Electrotechnology from the Technical University, as well as the members of the Frauenhofer Institute in Kaiserslautern. The goal of BioComp is to establish and apply computational methods in diverse areas of biology. The Molecular Genetics department participates with a project focused on aneuploidy-induced autophagy. Additionally, it provides access to state-of-the-art proteomics analysis to all members of research initiative through the Center of MS Analytics.